+ |
CDK2 | up-regulates activity
phosphorylation
|
CCNO |
0.465 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275615 |
Ser81 |
PSAARGGsPLPGPAQ |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
25364462 |
Phosphorylation of cyclin O, a novel cyclin family protein containing a cyclin-like domain, is involved in the activation of cyclin-dependent kinase 2|This activity was reduced in cells overexpressing cyclin O, in which the 81st serine had been replaced with alanine (S81A). These results suggest that cyclin O is a novel cyclin family protein that regulates CDK2 kinase activity, which is mediated by the phosphorylation of the 81st serine residue of cyclin O|CKD2 phosphorylates the 81st serine residue of cyclin O |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CCNO | up-regulates activity
binding
|
CDK2 |
0.465 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275616 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
25364462 |
Phosphorylation of cyclin O, a novel cyclin family protein containing a cyclin-like domain, is involved in the activation of cyclin-dependent kinase 2|This activity was reduced in cells overexpressing cyclin O, in which the 81st serine had been replaced with alanine (S81A). These results suggest that cyclin O is a novel cyclin family protein that regulates CDK2 kinase activity, which is mediated by the phosphorylation of the 81st serine residue of cyclin O |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CCNO | up-regulates activity
binding
|
CDK1 |
0.341 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275617 |
|
|
|
|
pmid |
sentence |
37197505 |
CDK2 is the predominant activating complex form of CCNO, but CCNO can bind to CDK1 to form an activating complex in the absence of CDK2. |
|
Publications: |
1 |
+ |
CCNO | up-regulates activity
binding
|
CDK13 |
0.274 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275618 |
|
|
|
|
pmid |
sentence |
37197505 |
Cyclin O promotes lung cancer progression and cetuximab resistance via cell cycle regulation and CDK13 interaction|CCNO promoted tumor cell proliferation and survival in vivo via CDK13| |
|
Publications: |
1 |