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Summary
Name
TGM1
Full Name
Protein-glutamine gamma-glutamyltransferase K
Synonyms
Epidermal TGase, Transglutaminase K, TG(K), TGK, TGase K, Transglutaminase-1, TGase-1 | KTG
Primary ID
P22735
Links
-
-
Type
protein
Relations
1
Function
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141).
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by mechanism
none
transcriptional regulation
by effect
none
down-regulates quantity by repression
by organism:
none
Homo sapiens
by tissue:
none
by cell-line
none
keratinocyte
Relations
Regulator
Mechanism
target
score
ℹ
+
HOXA7
down-regulates quantity by repression
transcriptional regulation
TGM1
0.2
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-254474
Homo sapiens
Keratinocyte
pmid
sentence
11435435
Antisense HOXA7 expression activated transglutaminase 1, involucrin, and keratin 10 message and protein levels, demonstrating that endogenous HOXA7 down-regulates multiple differentiation-specific keratinocyte genes.
Publications:
1
Organism:
Homo Sapiens