Summary

Name GLRA1
Full Name Glycine receptor subunit alpha-1
Synonyms Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit |
Primary ID P23415
Links - -
Type protein
Relations 5
Function Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png chemical activation GLRA1 0.8
Publications: 2 Organism: Homo Sapiens
Tissue: Retina, Spinal Cord, Brain Stem
+ up-regulates activity img/direct-activation.png chemical activation GLRA1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation GLRA1 0.8
Publications: 1 Organism: Xenopus Laevis
+ up-regulates activity img/direct-activation.png chemical activation GLRA1 0.8
Publications: 1 Organism: Homo Sapiens