| + |
glycine | up-regulates activity 
chemical activation
|
GLRA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258580 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18721822 |
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Retina, Spinal Cord, Brain Stem |
| + |
ethanol | up-regulates activity
chemical activation
|
GLRA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258495 |
|
|
Xenopus laevis |
Oocyte |
| pmid |
sentence |
| 8700149 |
Pharmacologically relevant concentrations of ethanol (10-200 mM) reversibly potentiated the glycine receptor function in all receptors. Ethanol potentiation depended on the glycine concentration used, with decreased potentiation observed at higher glycine concentrations. |
|
| Publications: |
1 |
Organism: |
Xenopus Laevis |
| + |
beta-alanine | up-regulates activity
chemical activation
|
GLRA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258581 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
taurine | up-regulates activity
chemical activation
|
GLRA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258579 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9009272 |
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GLRA1
- 
- 