| + |
GSK3A | down-regulates activity 
phosphorylation
|
FCAR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264856 |
Ser284 |
LTFARTPsVCK |
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 30766540 |
GSK-3 is constitutively active in the absence of cytokine stimulation and can phosphorylate S263, keeping FcalphaRI in the inactive state. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPP2CA | up-regulates activity 
dephosphorylation
|
FCAR |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264858 |
Ser284 |
LTFARTPsVCK |
in vitro |
|
| pmid |
sentence |
| 30766540 |
Furthermore, FcalphaRI activation is induced by protein phosphatase 2A (PP2A) after it dephosphorylates a single serine residue (S263) in the FcalphaRI intracellular tail |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GSK3B | down-regulates activity
phosphorylation
|
FCAR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264857 |
Ser284 |
LTFARTPsVCK |
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 30766540 |
GSK-3 is constitutively active in the absence of cytokine stimulation and can phosphorylate S263, keeping FcalphaRI in the inactive state. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FCAR | up-regulates 
|
Cytokine_production |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264860 |
|
|
Homo sapiens |
Neutrophil, Macrophage, Monocyte, Eosinophil |
| pmid |
sentence |
| 30766540 |
IgA-mediated immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, respiratory burst and cytokine release are mediated through FcalphaRI (CD89), an IgA-specific receptor that is expressed on monocytes, eosinophils, neutrophils and macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Immune complexes | up-regulates activity
relocalization
|
FCAR |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264859 |
|
|
|
|
| pmid |
sentence |
| 12768205 |
Both monomeric and dimeric IgA can bind to FcalphaRI, and monomeric or dimeric IgA immune complexes can activate phagocytosis and other immune responses through the clustering of FcalphaRI |
|
| Publications: |
1 |
| + |
FCAR | up-regulates
|
Phagocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30766540 |
IgA-mediated immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, respiratory burst and cytokine release are mediated through FcalphaRI (CD89), an IgA-specific receptor that is expressed on monocytes, eosinophils, neutrophils and macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FCAR | up-regulates
|
Immune_response |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264862 |
|
|
Homo sapiens |
Neutrophil, Macrophage, Monocyte, Eosinophil |
| pmid |
sentence |
| 30766540 |
IgA-mediated immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, respiratory burst and cytokine release are mediated through FcalphaRI (CD89), an IgA-specific receptor that is expressed on monocytes, eosinophils, neutrophils and macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FCAR
- 
- 