3.0
Summary
| Name |  CHM
|
| Full Name | Rab proteins geranylgeranyltransferase component A 1 |
| Synonyms | Choroideremia protein, Rab escort protein 1, REP-1, TCD protein | REP1, TCD |
| Primary ID | P24386 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. |
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