| + |
RABGGTB | up-regulates activity 
lipidation
|
RAB5A |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265573 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18532927 |
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab proteins. Rab GTPases need to be geranylgeranylated on either one or two cysteine residues in their Ctermini in order to localize to the correct intracellular membrane and be functional |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHM | down-regulates activity 
binding
|
RABGGTB |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18532927 |
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RABGGTB | up-regulates activity
lipidation
|
RAB3A |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265575 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18532927 |
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab proteins. Rab GTPases need to be geranylgeranylated on either one or two cysteine residues in their Ctermini in order to localize to the correct intracellular membrane and be functional |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RABGGTB
- 
- 