| + |
LMO2 | up-regulates quantity by expression 
transcriptional regulation
|
ERG |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253922 |
|
|
Homo sapiens |
T-cell Acute Lymphoblastic Leukemia Cell |
| pmid |
sentence |
| 21536859 |
We further demonstrate that ERG expression in primary human T-ALL cells is mediated by the binding of other T-cell oncogenes SCL/TAL1, LMO2, and LYL1 in concert with ERG, FLI1, and GATA3 to the ERG +85 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LMO2 | up-regulates 
binding
|
TAL1 |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46161 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 9020185 |
Transcriptional activity of tal1 in t cell acute lymphoblastic leukemia (t-all) requires rbtn1 or -2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LMO2 | up-regulates quantity by expression
transcriptional regulation
|
ANGPT2 |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198249 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22792348 |
Here, we identified angiopoietin-2 (ang-2), which encodes a major regulator of angiogenesis, as a direct transcriptional target of tal1,lyl1and lmo2. Knockdown of any of the three transcription factors in human blood and lymphatic endothelial cells caused ang-2 mrna and protein down-regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LMO2
- 
- 