Summary

Name PON1
Full Name Serum paraoxonase/arylesterase 1
Synonyms PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1 | PON
Primary ID P27169
Links - -
Type protein
Relations 2
Function Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PON1 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PON1 0.271
Publications: 1 Organism: Homo Sapiens