Relation Results

Summary

Name HLA-DMA
Full Name HLA class II histocompatibility antigen, DM alpha chain
Synonyms MHC class II antigen DMA, Really interesting new gene 6 protein | DMA, RING6
Primary ID P28067
Links - -
Type protein
Relations 2
Function Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules an ...
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Type: Score: Layout: SPV 
0.3290.404RFX complexHLA-DMACIITA

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Relations
Regulator
Mechanism
target
score ℹ
+ RFX complexup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMA 0.329
Identifier Residue Sequence Organism Cell Line
SIGNOR-253993 in vitro
pmid sentence
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex
Publications: 1 Organism: In Vitro
+ CIITAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMA 0.404
Identifier Residue Sequence Organism Cell Line
SIGNOR-254004
pmid sentence
The class II transactivator (CIITA) is a highly specific transcription factor that activates only genes known to be involved in the class II MHC processing pathway, including class II MHC, invariant chain, and HLA-DMA/B genes.
Publications: 1
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