+ |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DMB |
0.36 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254014 |
|
|
Homo sapiens |
B-lymphocyte |
pmid |
sentence |
9300700 |
The class II transactivator (CIITA) is a highly specific transcription factor that activates only genes known to be involved in the class II MHC processing pathway, including class II MHC, invariant chain, and HLA-DMA/B genes. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254010 |
|
|
Homo sapiens |
B-lymphocyte |
pmid |
sentence |
11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DMB |
0.373 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254016 |
|
|
Homo sapiens |
B-lymphocyte |
pmid |
sentence |
11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253999 |
|
|
in vitro |
|
pmid |
sentence |
11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |