Relation Results

Summary

Name HLA-DMB
Full Name HLA class II histocompatibility antigen, DM beta chain
Synonyms MHC class II antigen DMB, Really interesting new gene 7 protein | DMB, RING7
Primary ID P28068
Links - -
Type protein
Relations 4
Function Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules an ...
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Type: Score: Layout: SPV 
0.3570.37CIITAHLA-DMBRFX complex

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Relations
Regulator
Mechanism
target
score ℹ
+ CIITAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMB 0.357
Identifier Residue Sequence Organism Cell Line
SIGNOR-254010 Homo sapiens B-lymphocyte
pmid sentence
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment.
Identifier Residue Sequence Organism Cell Line
SIGNOR-254014 Homo sapiens B-lymphocyte
pmid sentence
The class II transactivator (CIITA) is a highly specific transcription factor that activates only genes known to be involved in the class II MHC processing pathway, including class II MHC, invariant chain, and HLA-DMA/B genes.
Publications: 2 Organism: Homo Sapiens
+ RFX complexup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMB 0.37
Identifier Residue Sequence Organism Cell Line
SIGNOR-254016 Homo sapiens B-lymphocyte
pmid sentence
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment.
Identifier Residue Sequence Organism Cell Line
SIGNOR-253999 in vitro
pmid sentence
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex
Publications: 2 Organism: Homo Sapiens, In Vitro
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