Summary

Name HTR2C
Full Name 5-hydroxytryptamine receptor 2C
Synonyms 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C | HTR1C
Primary ID P28335
Links - -
Type protein
Relations 10
Inhibitors Agomelatine
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png chemical inhibition HTR2C
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI3
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAO1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAZ
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAQ
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA15
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA12
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR2C
Publications: 1 Organism: Homo Sapiens