Summary

Name PTPRM
Full Name Receptor-type tyrosine-protein phosphatase mu
Synonyms Protein-tyrosine phosphatase mu, R-PTP-mu, EC 3.1.3.48 | PTPRL1
Primary ID P28827
Links - -
Type protein
Relations 2
Function Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). {ECO:0000269|PubMed:10753936, ECO:0000269|PubMed:16456543, ECO:0000269|PubMed:17761881, ECO:0000269|PubMed:21998202}.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png dephosphorylation CTNND1 0.524
Publications: 1 Organism: Homo Sapiens