4.0
Summary
| Name |  GJB2
|
| Full Name | Gap junction beta-2 protein |
| Synonyms | Connexin-26, Cx26 |
| Primary ID | P29033 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Epithelial–mesenchymal transition |
| Function | Structural component of gap junctions (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910, PubMed:16849369, PubMed:19384972). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:21094651, PubMed:16849369, PubMed:19384972). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ZEB2 | down-regulates quantity by repression 
transcriptional regulation
|
GJB2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GJB2 | down-regulates 
|
Epithelial-mesenchymal_transition | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DNM2 | down-regulates
binding
|
GJB2 | 0.331 |
| Publications: | 1 | Organism: | Homo Sapiens | |