| + |
Calcineurin |
dephosphorylation
|
DNM2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252317 |
Ser764 |
LQSASSHsPTPQRRP |
Rattus norvegicus |
|
| pmid |
sentence |
| 20496096 |
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PPP3CB |
dephosphorylation
|
DNM2 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248363 |
Ser764 |
LQSASSHsPTPQRRP |
Rattus norvegicus |
|
| pmid |
sentence |
| 20496096 |
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PPP3CA |
dephosphorylation
|
DNM2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248677 |
Ser764 |
LQSASSHsPTPQRRP |
Rattus norvegicus |
|
| pmid |
sentence |
| 20496096 |
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PPP3CC |
dephosphorylation
|
DNM2 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248508 |
Ser764 |
LQSASSHsPTPQRRP |
Rattus norvegicus |
|
| pmid |
sentence |
| 20496096 |
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SRC | down-regulates activity 
phosphorylation
|
DNM2 |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277539 |
Tyr597 |
NTEQRNVyKDLRQIE |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 33113375 |
We used cSrc-transformed NIH 3T3 fibroblasts to examine the effect of mutant Dyn2Y597. Similar to its effect in myotubes, Dyn2Y597F presented reduced enrichment at podosomes, whereas Dyn2Y597E clearly targeted podosome rosettes (Figures S9B and S9C). Moreover, Dyn2Y597F significantly reduced the podosome area, ECM degradation ability, and lifespan of the podosome in cSrc-transformed NIH 3T3 fibroblasts, whereas Dyn2Y597E displayed contradictory effects (Figures S9D–S9G). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PSTPIP1 | down-regulates
binding
|
DNM2 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178628 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18480402 |
We show that pstpip1 associates with the regulator of endocytosis, dynamin 2, and pstpip1 expression impairs transferrin uptake and endocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNX9 | up-regulates 
binding
|
DNM2 |
0.804 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133976 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15703209 |
Snx9 binds directly to bothdynamin-1 anddynamin-2. Moreover by stimulatingdynaminassembly, snx9 stimulatesdynamin's basal gtpase activity and potentiates assembly-stimulated gtpase activity on liposomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDNF | down-regulates quantity by repression 
transcriptional regulation
|
DNM2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252173 |
|
|
Rattus norvegicus |
Neural Stem Cell |
| pmid |
sentence |
| 15212950 |
We characterize the network of 43 genes induced by GDNF overproduction of neuronal progenitor cells (ST14A), which mainly regulate migration and differentiation of neuronal progenitor cells. GDNF down-regulates doublecortin, Paf-ah1b (Lis1), dynamin, and a-tubulin, which are involved in neocortical lamination and cytoskeletal reorganization. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
DNM2 | up-regulates quantity by stabilization
binding
|
VAV1 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259080 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 23537630 |
Disruption of the Dyn2-Vav1 interaction targets Vav1 to the lysosome for degradation via an interaction with the cytoplasmic chaperone Hsc70, resulting in a dramatic reduction of Vav1 protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNM2 | down-regulates
binding
|
GJB2 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205372 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25263585 |
This study identifies dynamin 2 (dyn2) as a cx26 interactor in yeast and mammalian cells / we demonstrate that dyn2 regulates cx26 endocytosis and ubiquitination |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNM2 | up-regulates
binding
|
MYO1C |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17257598 |
Dynamin bind directly to the sh3 domain of myo1e / an intriguing possibility is that binding of dynamin and synaptojanin to myo1e tail may activate motor activity since it has been demonstrated that myo1e atpase activity is autoinhibited by its sh3 domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2B |
dephosphorylation
|
DNM2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269990 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 20496096 |
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
DNM2
- 
- 