3.0
Summary
| Name |  PTPN4View Modifications |
| Full Name | Tyrosine-protein phosphatase non-receptor type 4 |
| Synonyms | EC 3.1.3.48, Protein-tyrosine phosphatase MEG1, MEG, PTPase-MEG1 | |
| Primary ID | P29074 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton. {ECO:0000250, ECO:0000250|UniProtKB:Q9WU22, ECO:0000269|PubMed:20086240, ECO:0000269|PubMed:25825441, ECO:0000269|PubMed:27246854}. |
dephosphorylation