Relation Results

Summary

Name ARID4A
Full Name AT-rich interactive domain-containing protein 4A
Synonyms ARID domain-containing protein 4A, Retinoblastoma-binding protein 1, RBBP-1 | RBBP1, RBP1
Primary ID P29374
Links - -
Type protein
Relations 2
Function DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen recep ...
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Type: Score: Layout: SPV 
0.43CDK2ARID4A

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK2down-regulates img/direct_inhibition.png phosphorylation ARID4A 0.43
Identifier Residue Sequence Organism Cell Line
SIGNOR-170451 Ser1007 QHNFSVAsPLTLSQD Homo sapiens
pmid sentence
We identified rbp1 as a novel cdk substrate. Rbp1 is phosphorylated by cdk2 on serines 864 and 1007, which are n- and c-terminal to the lxcxe motif, respectively. Cdk2-mediated phosphorylation of rbp1 or prb destabilizes their interaction in vitro, with concurrent phosphorylation of both proteins leading to their dissociation
Identifier Residue Sequence Organism Cell Line
SIGNOR-170455 Ser864 RKILGQSsPEKKIRI Homo sapiens
pmid sentence
In the present study we identified rbp1 as a novel cdk substrate. Rbp1 is phosphorylated by cdk2 on serines 864 and 1007, which are n- and c-terminal to the lxcxe motif, respectively. Cdk2-mediated phosphorylation of rbp1 or prb destabilizes their interaction in vitro, with concurrent phosphorylation of both proteins leading to their dissociation
Publications: 2 Organism: Homo Sapiens
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