Summary

Name MIP
Full Name Lens fiber major intrinsic protein
Synonyms Aquaporin-0, MIP26, MP26 | AQP0
Primary ID P30301
Links - -
Type protein
Relations 1
Function Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation MIP 0.315
Publications: 1 Organism: In Vitro