Relation Results

Summary

Name PPIF
Full Name Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Synonyms PPIase F, Cyclophilin D, CyP-D, CypD, Cyclophilin F, Mitochondrial cyclophilin, CyP-M, Rotamase F | CYP3
Primary ID P30405
Links - -
Type protein
Relations 3
Function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20 ...
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Type: Score: Layout: SPV 
0.3850.20.2GSK3BPPIFAKT2ATP5PO

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ GSK3Bup-regulates activity img/direct-activation.png phosphorylation PPIF 0.385
Identifier Residue Sequence Organism Cell Line
SIGNOR-264880 Ser191 IESFGSKsGRTSKKI Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion|We conclude that CypD phosphorylation at S191 residue leads to its binding to OSCP and thus sensitizes mPTP opening for the subsequent cell death.|Under baseline condition (WT group), the phosphorylation of CypD by a kinase (e.g. GSK3beta) at S191 induces its translocation to the OSCP, to favor mPTP opening and subsequent cell death at reperfusion.
Publications: 1 Organism: Homo Sapiens
+ AKT2up-regulates activity img/direct-activation.png phosphorylation PPIF 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276875 Ser31 LPAARACsKGSGDPS Homo sapiens LN-229 Cell
pmid sentence
In turn, mitochondrial Akt2 phosphorylates Ser31 in cyclophilin D (CypD), a regulator of organelle functions. Akt2-phosphorylated CypD supports mitochondrial bioenergetics and opposes tumor cell death, conferring resistance to PI3K therapy.
Publications: 1 Organism: Homo Sapiens
+ PPIFup-regulates activity img/direct-activation.png binding ATP5PO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264881 Homo sapiens HEK-293 Cell
pmid sentence
We here hypothesized that CypD phosphorylation on its residue S191 induces its translocation and binding to the OSCP to favor mPTP opening. 
Publications: 1 Organism: Homo Sapiens
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