| + |
TLX1 | down-regulates activity 
binding
|
RB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240725 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 15897879 |
ectopic HOX11 expression resulted in hyperphosphorylation of the retinoblastoma protein (Rb), which correlated with inhibition of the major Rb serine/threonine phosphatase PP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLX1 | down-regulates activity
binding
|
ETS1 |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259097 |
|
|
Homo sapiens |
T-lymphoblastic Leukemia Cell Line |
| pmid |
sentence |
| 22516263 |
We show that the cortical thymic maturation arrest in T-lineage ALLs that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1, leading to repression of T cell receptor (TCR) α enhanceosome activity and blocked TCR-Jα rearrangement. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLX1 | down-regulates activity
binding
|
PPP2CB |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240722 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 15897879 |
HOX11 also inhibited PP2A serine/threonine phosphatase activity concomitant with stimulation of the AKT/PKB signaling cascade. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLX1 | down-regulates activity
binding
|
PPP2CA |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240719 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 15897879 |
HOX11 also inhibited PP2A serine/threonine phosphatase activity concomitant with stimulation of the AKT/PKB signaling cascade. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TLX1
- 
- 