| + |
CDK4 | down-regulates 
phosphorylation
|
RB1 |
0.931 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135181 |
Ser249 |
AVIPINGsPRTPRRG |
Homo sapiens |
|
| pmid |
sentence |
| 15809340 |
Phosphorylated by cdk6 and cdk4, and subsequently by cdk2 at ser-567 in g1, thereby releasing e2f1 which is then able to activate cell growth. Here we show that although these cdks phosphorylate multiple residues in prb, they do so with different residue selectivities in vitro;thr821 and thr826 are preferentially phosphorylated by cdk6 and cdk4, respectively. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200483 |
Ser780 |
STRPPTLsPIPHIPR |
Homo sapiens |
|
| pmid |
sentence |
| 23336272 |
Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200487 |
Ser795 |
SPYKFPSsPLRIPGG |
Homo sapiens |
|
| pmid |
sentence |
| 23336272 |
Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135185 |
Ser811 |
IYISPLKsPYKISEG |
Homo sapiens |
|
| pmid |
sentence |
| 15809340 |
Phosphorylated by cdk6 and cdk4, and subsequently by cdk2 at ser-567 in g1, thereby releasing e2f1 which is then able to activate cell growth. Here we show that although these cdks phosphorylate multiple residues in prb, they do so with different residue selectivities in vitro;thr821 and thr826 are preferentially phosphorylated by cdk6 and cdk4, respectively. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47899 |
Thr826 |
LPTPTKMtPRSRILV |
Homo sapiens |
|
| pmid |
sentence |
| 9139732 |
We demonstrate that phosphorylation by either cdk2-cyclin a, which phosphorylates t821, or cdk4-cyclin d1, which phosphorylates threonine 826, can disable prb for subsequent binding of an lxcxe protein. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Pathways: | Pancreatic ductal adenocarcinoma (PDA) |
| + |
CDK1 | down-regulates
phosphorylation
|
RB1 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21548 |
Ser249 |
AVIPINGsPRTPRRG |
Homo sapiens |
|
| pmid |
sentence |
| 1756735 |
The retinoblastoma gene product (prb) is a nuclear phosphoprotein that is thought to play a key role in the negative regulation of cellular proliferation. The active form of prb is underphosphorylated. Using synthetic peptides corresponding to potential cdc2 phosphorylation sites, we have developed a strategy which has allowed the identification of five sites. S249, t252, t373, s807 and s811 are phosphorylated in vivo, and in each case these sites correspond closely to the consensus sequence for phosphorylation by p34cdc2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21552 |
Ser807 |
PGGNIYIsPLKSPYK |
Homo sapiens |
|
| pmid |
sentence |
| 1756735 |
The retinoblastoma gene product (prb) is a nuclear phosphoprotein that is thought to play a key role in the negative regulation of cellular proliferation. The active form of prb is underphosphorylated. Using synthetic peptides corresponding to potential cdc2 phosphorylation sites, we have developed a strategy which has allowed the identification of five sites. S249, t252, t373, s807 and s811 are phosphorylated in vivo, and in each case these sites correspond closely to the consensus sequence for phosphorylation by p34cdc2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21556 |
Ser811 |
IYISPLKsPYKISEG |
Homo sapiens |
|
| pmid |
sentence |
| 1756735 |
The retinoblastoma gene product (prb) is a nuclear phosphoprotein that is thought to play a key role in the negative regulation of cellular proliferation. The active form of prb is underphosphorylated. Using synthetic peptides corresponding to potential cdc2 phosphorylation sites, we have developed a strategy which has allowed the identification of five sites. S249, t252, t373, s807 and s811 are phosphorylated in vivo, and in each case these sites correspond closely to the consensus sequence for phosphorylation by p34cdc2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21560 |
Thr252 |
PINGSPRtPRRGQNR |
Homo sapiens |
|
| pmid |
sentence |
| 1756735 |
The retinoblastoma gene product (prb) is a nuclear phosphoprotein that is thought to play a key role in the negative regulation of cellular proliferation. The active form of prb is underphosphorylated. Using synthetic peptides corresponding to potential cdc2 phosphorylation sites, we have developed a strategy which has allowed the identification of five sites. S249, t252, t373, s807 and s811 are phosphorylated in vivo, and in each case these sites correspond closely to the consensus sequence for phosphorylation by p34cdc2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21564 |
Thr373 |
VNVIPPHtPVRTVMN |
Homo sapiens |
|
| pmid |
sentence |
| 1756735 |
The retinoblastoma gene product (prb) is a nuclear phosphoprotein that is thought to play a key role in the negative regulation of cellular proliferation. The active form of prb is underphosphorylated. Using synthetic peptides corresponding to potential cdc2 phosphorylation sites, we have developed a strategy which has allowed the identification of five sites. S249, t252, t373, s807 and s811 are phosphorylated in vivo, and in each case these sites correspond closely to the consensus sequence for phosphorylation by p34cdc2. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
RB1 |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168178 |
Ser567 |
SLAWLSDsPLFDLIK |
Homo sapiens |
|
| pmid |
sentence |
| 20871633 |
P38 bypasses the cell cycle-associated hierarchical phosphorylation and directly phosphorylates rb on ser567, which is not phosphorylated during the normal cell cycle. Phosphorylation by p38, but not cdks, triggers an interaction between rb and the human homolog of murine double minute 2 (hdm2), leading to degradation of rb, release of e2f1 and cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
CyclinE/CDK2 | down-regulates activity
phosphorylation
|
RB1 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250747 |
Ser608 |
TAADMYLsPVRSPKK |
|
C-33A Cell |
| pmid |
sentence |
| 10207050 |
In the present assay, ΔP3,4HA repressed E2F-mediated transcription similarly to wild-type pRB, suggesting that phosphorylation at other sites on ΔP3,4HA can disrupt its interaction with E2F and that these two sites are not sufficient to regulate E2F binding on DNA. This result is consistent with another report which showed that mutation of the human sites 8 and 9 (human Ser608 and Ser612) repressed E2F-mediated transcription to the same level as wild-type pRB (2). | Surprisingly, no one CDK site regulated the interaction of pRB with E2F when E2F was bound to DNA. Instead, disruption of transcriptional repression resulted from accumulation of phosphate groups on the RB molecule. |
|
| Publications: |
1 |
| Pathways: | FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, IGF and Myogenesis, p53 in cancer |
| + |
CHEK2 | up-regulates activity 
phosphorylation
|
RB1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153908 |
Ser612 |
MYLSPVRsPKKKGST |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17380128 |
Phosphorylation of prb at ser612 by chk1/2 leads to a complex between prb and e2f-1 after dna damageprb inhibits cell cycle progression through interactions with the e2f family of transcription factors. Here, we report that dna damage induced not only the dephosphorylation of prb at cdk phosphorylation sites and the binding of prb to e2f-1, but also the phosphorylation of prb at ser612. Phosphorylation of prb at ser612 enhanced the formation of a complex between prb and e2f-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer |
| + |
CHEK1 | up-regulates activity
phosphorylation
|
RB1 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153904 |
Ser612 |
MYLSPVRsPKKKGST |
Homo sapiens |
|
| pmid |
sentence |
| 17380128 |
These results suggest that ser612 is phosphorylated by chk1/2 after dna damage, leading to the formation of prb-e2f-1. phosphorylation of prb at ser612 enhanced the formation of a complex between prb and e2f-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Cell cycle: G2/M phase transition |
| + |
PRKCB | down-regulates activity
phosphorylation
|
RB1 |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280083 |
Ser780 |
STRPPTLsPIPHIPR |
Homo sapiens |
|
| pmid |
sentence |
| 29088742 |
The exact mechanism by which PKCbeta degrades RB is unknown.|To attribute increased RB phosphorylation specifically to PKC\u03b2, we transiently transfected PKC\u03b2 -/- hepatocytes, and reintroduction of PKC\u03b2 specifically resulted in increased in phospho-RB (Ser780) levels, further supporting that PKC\u03b2 phosphorylates RB specifically at Ser780 without affecting phosphorylation at other residues (Ser807 and Ser811) (Figure xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinD/CDK4 | down-regulates activity
phosphorylation
|
RB1 |
0.868 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216988 |
Ser780 |
STRPPTLsPIPHIPR |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23336272 |
Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250759 |
Ser788 |
PIPHIPRsPYKFPSS |
in vitro |
|
| pmid |
sentence |
| 9139732 |
In summary, we have shown evidence that CDK4-cyclin D1 phosphorylates Thr5, Ser249, Thr252, Thr356, Thr373, Ser788, Ser795, Ser807, Ser811, and Thr826 of pRB. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216992 |
Ser795 |
SPYKFPSsPLRIPGG |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23336272 |
Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250760 |
Thr356 |
DSFETQRtPRKSNLD |
in vitro |
|
| pmid |
sentence |
| 9139732 |
In summary, we have shown evidence that CDK4-cyclin D1 phosphorylates Thr5, Ser249, Thr252, Thr356, Thr373, Ser788, Ser795, Ser807, Ser811, and Thr826 of pRB. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250762 |
Thr5 |
tPRKTAAT |
in vitro |
|
| pmid |
sentence |
| 9139732 |
In summary, we have shown evidence that CDK4-cyclin D1 phosphorylates Thr5, Ser249, Thr252, Thr356, Thr373, Ser788, Ser795, Ser807, Ser811, and Thr826 of pRB. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216957 |
Thr826 |
LPTPTKMtPRSRILV |
Homo sapiens |
|
| pmid |
sentence |
| 9139732 |
We demonstrate that phosphorylation by either cdk2-cyclin a, which phosphorylates t821, or cdk4-cyclin d1, which phosphorylates threonine 826, can disable prb for subsequent binding of an lxcxe protein. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, IGF and Myogenesis, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma |
| + |
CTDSPL | up-regulates activity
dephosphorylation
|
RB1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248304 |
Ser807 |
PGGNIYIsPLKSPYK |
Homo sapiens |
|
| pmid |
sentence |
| 15051889 |
ppRB (RB phosphorylated at Ser-807/811|Possible Mechanisms of HYA22 Action in Tumorigenesis: Dephosphorylation of RB by Transient Expression of HYA22 Isoforms. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248305 |
Ser811 |
IYISPLKsPYKISEG |
Homo sapiens |
|
| pmid |
sentence |
| 15051889 |
ppRB (RB phosphorylated at Ser-807/811|Possible Mechanisms of HYA22 Action in Tumorigenesis: Dephosphorylation of RB by Transient Expression of HYA22 Isoforms. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CyclinC/CDK3 | down-regulates activity
phosphorylation
|
RB1 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273181 |
Ser811 |
IYISPLKsPYKISEG |
Homo sapiens |
|
| pmid |
sentence |
| 15084261 |
The active form of prb is underphosphorylated. Cdk3/cyclin-c-mediated phosphorylation at ser-807 and ser-811 is required for g0-g1 transition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK3 | down-regulates
phosphorylation
|
RB1 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124212 |
Ser811 |
IYISPLKsPYKISEG |
Homo sapiens |
|
| pmid |
sentence |
| 15084261 |
The active form of prb is underphosphorylated. Cdk3/cyclin-c-mediated phosphorylation at ser-807 and ser-811 is required for g0-g1 transition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK6 | down-regulates
phosphorylation
|
RB1 |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135189 |
Ser811 |
IYISPLKsPYKISEG |
Homo sapiens |
|
| pmid |
sentence |
| 15809340 |
Phosphorylated by cdk6 and cdk4, and subsequently by cdk2 at ser-567 in g1, thereby releasing e2f1 which is then able to activate cell growth. Here we show that although these cdks phosphorylate multiple residues in prb, they do so with different residue selectivities in vitro;thr821 and thr826 are preferentially phosphorylated by cdk6 and cdk4, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK |
Fatal error: Uncaught TypeError: implode(): Argument #2 ($array) must be of type ?array, string given in /home/prisca/signor/relation_result.php:2084
Stack trace:
#0 /home/prisca/signor/relation_result.php(2084): implode()
#1 {main}
thrown in /home/prisca/signor/relation_result.php on line 2084
4.0
RB1
- 
- 