Summary

Name SLC6A4
Full Name Sodium-dependent serotonin transporter
Synonyms SERT, 5HT transporter, 5HTT, Solute carrier family 6 member 4 | HTT, SERT
Primary ID P31645
Links - -
Type protein
Relations 23
Inhibitors venlafaxine; dothiepin; trimipramine; paroxetine; 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine; Phenelzine; fluoxetine; desipramine; (S)-duloxetine; lofepramine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; Norzotepine; doxepin; protriptyline; zotepine; levomilnacipran; clomipramine; atomoxetine; nefazodone
Function Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation SLC6A4 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization serotonin 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A4 0.8
Publications: 1 Organism: In Vitro