Summary

Name PRKG1
Full Name cGMP-dependent protein kinase 1
Synonyms cGK 1, cGK1, cGMP-dependent protein kinase I, cGKI | PRKG1B, PRKGR1A, PRKGR1B
Primary ID Q13976
Links - -
Type protein
Relations 57
Pathways Axon guidance
Function Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways

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Regulator Mechanism target score ℹ
+ PRKG1up-regulates activity img/direct-activation.png phosphorylation PRKAR1A 0.234
Publications: 1 Organism: Homo Sapiens
+ PRKG1