3.0
Summary
| Name |  YWHABView Modifications |
| Full Name | 14-3-3 protein beta/alpha |
| Synonyms | Protein 1054, Protein kinase C inhibitor protein 1, KCIP-1 |
| Primary ID | P31946 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | IKBKB | down-regulates 
phosphorylation
|
YWHAB | 0.377 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK8 | down-regulates
phosphorylation
|
YWHAB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCD | down-regulates
phosphorylation
|
YWHAB | 0.505 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCZ | down-regulates activity
phosphorylation
|
YWHAB | 0.375 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | YWHAB | down-regulates activity
binding
|
NEFL | 0.257 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | YWHAB | down-regulates
binding
|
SRPK2 | 0.335 |
| Publications: | 1 | Organism: | Homo Sapiens | |