3.0
Summary
| Name |  SRPK2View Modifications |
| Full Name | SRSF protein kinase 2 |
| Synonyms | SFRS protein kinase 2, Serine/arginine-rich protein-specific kinase 2, SR-protein-specific kinase 2 |
| Primary ID | P78362 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:9472028, PubMed:18559500, PubMed:21056976). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRPK2 | up-regulates 
phosphorylation
|
ACIN1 | 0.488 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRPK2 | up-regulates activity
phosphorylation
|
LGMN | 0.2 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | RPS6KB1 | up-regulates activity
phosphorylation
|
SRPK2 | 0.363 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1A1 | up-regulates activity
phosphorylation
|
SRPK2 | 0.253 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates
phosphorylation
|
SRPK2 | 0.478 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | AKT | up-regulates
phosphorylation
|
SRPK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | SRPK2 | up-regulates quantity by expression 
transcriptional regulation
|
CCND1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | YWHAB | down-regulates 
binding
|
SRPK2 | 0.336 |
| Publications: | 1 | Organism: | Homo Sapiens | |