Summary

Name SFN
Full Name 14-3-3 protein sigma
Synonyms Epithelial cell marker protein 1, Stratifin | HME1
Primary ID P31947
Links - -
Type protein
Relations 4
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation SFN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SFN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SFN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization SNAI1 0.14
Publications: 1 Organism: Homo Sapiens