3.0
Summary
| Name |  TRIM25View Modifications |
| Full Name | E3 ubiquitin/ISG15 ligase TRIM25 |
| Synonyms | Estrogen-responsive finger protein, RING finger protein 147, RING-type E3 ubiquitin transferase, 2.3.2.27, RING-type E3 ubiquitin transferase TRIM25, Tripartite motif-containing protein 25, Ubiquitin/ISG15-conjugating enzyme TRIM25, Zinc finger protein 147 | EFP, RNF147, ZNF147 |
| Primary ID | Q14258 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849, PubMed:33849980). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TRIM25 | down-regulates quantity by destabilization 
polyubiquitination
|
MAVS | 0.763 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | LUBAC | down-regulates quantity by destabilization
polyubiquitination
|
TRIM25 | 0.484 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM25 | down-regulates quantity by destabilization
polyubiquitination
|
AMFR | 0.373 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM25 | down-regulates quantity by destabilization
polyubiquitination
|
ZFHX3 | 0.466 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
TRIM25 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM25 | down-regulates quantity by destabilization
polyubiquitination
|
KLF5 | 0.499 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | TRIM25 | down-regulates quantity by destabilization
ubiquitination
|
SFN | 0.595 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | TRIM25 | up-regulates activity
polyubiquitination
|
DDX58 | 0.797 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM25 | down-regulates quantity by destabilization
ubiquitination
|
GPI | 0.255 |
| Publications: | 1 | Organism: | Homo Sapiens | |