| + |
CCR1 | up-regulates 
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25230753 |
CCL3, an eosinophil precursor-produced chemokine that signals through CCR1, promotes terminal differentiation of CCR1-positive eosinophil precursors in the absence of IL-5, highlighting an autocrine loop capable of sustaining eosinophil differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL3 | up-regulates 
binding
|
CCR1 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254366 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10734056 |
CCR1 is also activated by MIP-1α, MCP-2, and MCP-3, although maximum responses are only obtained with RANTES and MIP-1α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR1 | up-regulates activity
phosphorylation
|
ERK1/2 |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255118 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20219869 |
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. Furthermore, stimulation of myoblasts with CCL2, CCL3, or CCL4 was sufficient to induce phosphorylation and activation of ERK1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CCL7 | up-regulates
binding
|
CCR1 |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254368 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14991608 |
For example, 11 chemokines are reported to bind to CC chemokine receptor (CCR) 1, including macrophage inflammatory protein (MIP)‐1α , MIP‐1β, MIP‐1δ, regulated upon activation, normal T cell‐expressed and secreted (RANTES), monocyte chemotactic peptide (MCP)‐1, MCP‐2, MCP‐3, MCP‐4, leukotactin‐1 (Lkn‐1), myeloid progenitor inhibitory factor (MPIF)‐1, and hemofiltrate CC chemokine (HCC)‐1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL5 | up-regulates
binding
|
CCR1 |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254367 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10734056 |
RANTES interacts with specific cell surface receptors, which are coupled to pertussis toxin-sensitive guanine nucleotide regulatory proteins (G protein) to activate effectors such as phospholipase C (PLC), ion channels, phospholipase D, and protein kinase C. In addition to the CCR1 receptor, RANTES activates several members of the CC subfamily of chemokine receptors including CCR3, CCR4, and CCR5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL3 | up-regulates activity
binding
|
CCR1 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20219869 |
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCR1
- 
- 