| + |
KAT6A | up-regulates quantity by expression 
transcriptional regulation
|
CCL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251726 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 12771199 |
We further demonstrate that the histone acetyltransferase, MOZ, can activate the MIP-1a promoter in T-cells and that this activation is largely dependent upon the proximal RUNX site. Moreover, we show that co-expression of MOZ and RUNX1 can activate the MIP-1a promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL3 | up-regulates activity
binding
|
CCR5 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251724 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15075201 |
The purpose of this study was to determine whether certain chemokines, which are highly expressed in injured skeletal muscle, are involved in the repair and functional recovery of the muscle after traumatic injury. In wild-type control mice, mRNA transcripts of macrophage inflammatory protein (MIP)-1, MIP-1, and monocyte chemoattractant protein (MCP)-1 as well as their major receptors, CCR5 and CCR2, increased after freeze injury and gradu- ally returned to control (uninjured) levels by 14 days. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255115 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20219869 |
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
maraviroc | down-regulates 
chemical inhibition
|
CCL3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL3 | up-regulates
binding
|
CCR1 |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254366 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10734056 |
CCR1 is also activated by MIP-1α, MCP-2, and MCP-3, although maximum responses are only obtained with RANTES and MIP-1α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL3 | up-regulates activity
binding
|
CCR2 |
0.55 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251723 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15075201 |
The purpose of this study was to determine whether certain chemokines, which are highly expressed in injured skeletal muscle, are involved in the repair and functional recovery of the muscle after traumatic injury. In wild-type control mice, mRNA transcripts of macrophage inflammatory protein (MIP)-1, MIP-1, and monocyte chemoattractant protein (MCP)-1 as well as their major receptors, CCR5 and CCR2, increased after freeze injury and gradu- ally returned to control (uninjured) levels by 14 days. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CCL3 | up-regulates activity
binding
|
CCR1 |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20219869 |
The investigators showed that myoblasts constitutively express receptors for CCL2 (CCR2), CCL3 (CCR1 and CCR5), and CCL4 (CCR5), and that stimulation with either CCL2 or CCL4 was sufficient to promote myoblast proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX1 | up-regulates quantity by expression
transcriptional regulation
|
CCL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251738 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 12771199 |
We show that RUNX1 can specifically bind to both RUNX sites but that only the proximal RUNX site is essential for PMA/ PHA stimulation of the MIP-1a promoter in Jurkat T-cells. We also show that the endogenous MIP-1a promoter is constitutively bound by RUNX1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCL3
- 
- 