| + |
PPP2CB | down-regulates activity 
dephosphorylation
|
ELF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248591 |
Thr231 |
CPKYIKWtQREKGIF |
Homo sapiens |
|
| pmid |
sentence |
| 18714041 |
Elf-1 enhances the expression of CD3zeta, whereas it suppresses the expression of FcRgamma gene and lupus T cells have decreased amounts of DNA-binding 98 kDa form of Elf-1. We show that the aberrantly increased PP2A in lupus T cells dephosphorylates Elf-1 at Thr-231. Dephosphorylation results in limited expression and binding of the 98 kDa Elf-1 form to the CD3zeta and FcRgamma promoters. Suppression of the expression of the PP2A leads to increased expression of CD3zeta and decreased expression of FcRgamma genes and correction of the early signaling response |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | down-regulates activity
dephosphorylation
|
ELF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248634 |
Thr231 |
CPKYIKWtQREKGIF |
Homo sapiens |
|
| pmid |
sentence |
| 18714041 |
Elf-1 enhances the expression of CD3zeta, whereas it suppresses the expression of FcRgamma gene and lupus T cells have decreased amounts of DNA-binding 98 kDa form of Elf-1. We show that the aberrantly increased PP2A in lupus T cells dephosphorylates Elf-1 at Thr-231. Dephosphorylation results in limited expression and binding of the 98 kDa Elf-1 form to the CD3zeta and FcRgamma promoters. Suppression of the expression of the PP2A leads to increased expression of CD3zeta and decreased expression of FcRgamma genes and correction of the early signaling response |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELF1 | up-regulates quantity by expression 
transcriptional regulation
|
IL2RA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240193 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 7862168 |
The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli. Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified. We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y). Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated. Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELF1 | up-regulates quantity by expression
transcriptional regulation
|
CD68 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254282 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 12676954 |
Band shift experiments show that PU.1 associates with the -89 site whereas, Elf-1 preferentially binds the -106 Ets binding site and enhances CD68 activity in vitro. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ELF1 | down-regulates quantity by repression 
transcriptional regulation
|
FCER1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254287 |
|
|
Homo sapiens |
KU-812 Cell |
| pmid |
sentence |
| 11971001 |
Transcriptional regulation of the gene-encoding human Fc epsilon RI alpha-chain was analyzed in detail. EMSA revealed that either YY1 or PU.1 bound to the region close to that recognized by Elf-1|These up-regulating effects of PU.1 and YY1 with GATA-1 were inhibited by overexpression of Elf-1, indicating that Elf-1 serves as a repressor for the alpha-chain gene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ELF1
- 
- 