Summary

Name FCER1A
Full Name High affinity immunoglobulin epsilon receptor subunit alpha
Synonyms Fc-epsilon RI-alpha, FcERI, IgE Fc receptor subunit alpha | FCE1A
Primary ID P12319
Links - -
Type protein
Relations 5
Pathways Mast cell: FCERI
Function Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

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Relations

Regulator Mechanism target score ℹ
+ SPI1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FCER1A 0.278
Publications: 1 Organism: Homo Sapiens
+ YY1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FCER1A 0.2
Publications: 1 Organism: Homo Sapiens
+ FCER1Aform complex img/form-complex.png binding FCER1 0.668
Publications: 1 Organism: Homo Sapiens
+ ELF1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FCER1A 0.2
Publications: 1 Organism: Homo Sapiens
+ GATA1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FCER1A 0.316
Publications: 1 Organism: Homo Sapiens