+ |
PTPN6 | down-regulates
dephosphorylation
|
CSF2RB |
0.5 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-114597 |
Tyr628 |
PPPGSLEyLCLPAGG |
Homo sapiens |
|
pmid |
sentence |
11812650 |
However, inhibition of shp2 binding to betac, did not prevent tyrosine phosphorylation of shp2. Interestingly, this same phosphopeptide served as a substrate for the tyrosine phosphatase activity of both shp1 and shp2. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-48561 |
Tyr628 |
PPPGSLEyLCLPAGG |
Homo sapiens |
|
pmid |
sentence |
9162089 |
However, inhibition of shp2 binding to betac, did not prevent tyrosine phosphorylation of shp2. Interestingly, this same phosphopeptide served as a substrate for the tyrosine phosphatase activity of both shp1 and shp2. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
PTPN11 | up-regulates
dephosphorylation
|
CSF2RB |
0.489 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-48557 |
|
|
Homo sapiens |
|
pmid |
sentence |
9162089 |
Shp2 is thought to act as a positive mediator of growth factor signals.. Hp2 could act as an adaptor between the activated c and grb2, thus leading to activation of the ras/mitogen-activated protein kinase pathway, known to be activated by il-3 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
BCR-ABL | up-regulates activity
phosphorylation
|
CSF2RB |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255814 |
|
|
Homo sapiens |
M-07E Cell |
pmid |
sentence |
8758906 |
We demonstrated that Bcr-Abl co-immunoprecipitates with, and constitutively phosphorylates, the common βc,subunit of the interleukin 3 and granulocyte/macrophage-colony stimulating factor receptors.We demonstrate that Bcr-Abl interacts with the common βc subunit of the IL-3 family of receptors and phosphorylates it on tyrosine. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CSF2RB | form complex
binding
|
CSF2RA/CSF2RB |
0.864 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255583 |
|
|
Homo sapiens |
Monocyte |
pmid |
sentence |
9680354 |
The high-affinity GMR is known to be composed of a specific ligand-binding alpha subunit (GMRα) and a common beta subunit (βc), which is also a component of the interleukins-3 (IL-3) and -5 (IL-5) receptors. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Skeletal Muscle |