Monocyte: Macrophage differentiation

Pathway ID: SIGNOR-MonoMAC

Description: The CSF-1 receptor (CSF-1R) signaling pathway plays important roles in development and in innate immunity by regulating the development of most tissue macrophages. Upon binding with its ligand, CSF1R activates several downstream entities, leading to the inhibition of monocytes proliferation while enhancing their differentiation into macrophages.

Curated by: Alessandro Palma

16 Seed Entities

Organism:
Name Primary ID
CSF2 P04141
CSF1R P07333
Proliferation SIGNOR-PH4
Macrophage_differentiation SIGNOR-PH99
CSF2RB P32927
CSF1 P09603
CSF2RA P15509
IL34 Q6ZMJ4
STAT5A P42229
ERK1/2 SIGNOR-PF1
JAK2 O60674
Survival SIGNOR-PH13
SOCS1 O15524
PI3K SIGNOR-C156
CSF2RA/CSF2RB SIGNOR-C212
PLCG2 P16885