| + |
JAK2 | up-regulates activity 
phosphorylation
|
CSF2RA/CSF2RB |
0.568 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256001 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 8977526 |
JAK2 is a primary kinase regulating all the known activities of GM-CSF. JAK2 mediates GM-CSF induced c-fos activation through receptor phosphorylation and Shc/PTP 1D activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255584 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 19436055 |
The GM-CSF receptor does not have intrinsic tyrosine kinase activity, but associates with the tyrosine kinase Jak2 that is required for βc transphosphorylation and the initiation of signaling and biological activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML |
| + |
BCR-ABL | up-regulates activity
phosphorylation
|
CSF2RA/CSF2RB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255999 |
|
|
Homo sapiens |
M-07E Cell |
| pmid |
sentence |
| 8758906 |
We demonstrated that Bcr-Abl co-immunoprecipitates with, and constitutively phosphorylates, the common βc,subunit of the interleukin 3 and granulocyte/macrophage-colony stimulating factor receptors.We demonstrate that Bcr-Abl interacts with the common βc subunit of the IL-3 family of receptors and phosphorylates it on tyrosine. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256123 |
|
|
Mus musculus |
Bone Marrow Stem Cell |
| pmid |
sentence |
| 14500898 |
This up-regulation required BCR-ABL tyrosine kinase activity and led to IL-3Rbetac/beta chain tyrosine phosphorylation in the absence of detectable IL-3 production. These results suggested that cytokine-independent IL-3 receptor activation could be a dominant signaling component in BCR-ABL-induced leukemogenesis. However, the IL-3Rβc/β chain could act as a cofactor in BCR-ABL-induced leukemogenesis by activation of its many known oncogenic signaling pathways. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML |
| + |
CSF2RB | form complex 
binding
|
CSF2RA/CSF2RB |
0.864 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255583 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 9680354 |
The high-affinity GMR is known to be composed of a specific ligand-binding alpha subunit (GMRα) and a common beta subunit (βc), which is also a component of the interleukins-3 (IL-3) and -5 (IL-5) receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
CSF2RA/CSF2RB | up-regulates activity 
|
ERK1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255586 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 19436055 |
As a consequence of Jak2 activation and tyrosine phosphorylation of the cytoplasmic tail of beta-c, Src homology 2 and phosphotyrosine binding domain proteins are recruited to the active receptor and initiate the major tyrosine phosphorylation-dependent signaling pathways, including the Jak/signal transducer and activator of transcription, Ras/mitogen-activated protein kinase, and phosphatidylinositol 3 (PI-3) kinase pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML |
| + |
CSF2RA | form complex
binding
|
CSF2RA/CSF2RB |
0.864 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9680354 |
The high-affinity GMR is known to be composed of a specific ligand-binding alpha subunit (GMRα) and a common beta subunit (βc), which is also a component of the interleukins-3 (IL-3) and -5 (IL-5) receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSF2 | up-regulates
binding
|
CSF2RA/CSF2RB |
0.856 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255581 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 9680354 |
GM-CSF elicits these diverse responses through the GM-CSF receptor (GMR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
CSF2RA/CSF2RB | up-regulates activity
binding
|
PI3K |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19436055 |
As a consequence of Jak2 activation and tyrosine phosphorylation of the cytoplasmic tail of βc, Src homology 2 and phosphotyrosine binding domain proteins are recruited to the active receptor and initiate the major tyrosine phosphorylation-dependent signaling pathways, including the Jak/signal transducer and activator of transcription, Ras/mitogen-activated protein kinase, and phosphatidylinositol 3 (PI-3) kinase pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML |
3.0
CSF2RA/CSF2RB