4.0
Summary
| Name |  ACSL1
|
| Full Name | Long-chain-fatty-acid--CoA ligase 1 |
| Synonyms | Acyl-CoA synthetase 1, ACS1, Long-chain acyl-CoA synthetase 1, LACS 1, Long-chain acyl-CoA synthetase 2, LACS 2, Long-chain fatty acid-CoA ligase 2, Palmitoyl-CoA ligase 1, Palmitoyl-CoA ligase 2 | FACL1, FACL2, LACS, LACS1, LACS2 |
| Primary ID | P33121 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Fatty Acid Synthesis |
| Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPARA | up-regulates quantity by expression 
transcriptional regulation
|
ACSL1 | 0.555 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACSL1 | up-regulates quantity 
chemical modification
|
palmitoyl-CoA | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Fatty Acid Synthesis | |||
| + | ACSL1 | down-regulates quantity 
chemical modification
|
hexadecanoic acid | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Fatty Acid Synthesis | |||