| + |
BTC | up-regulates 
binding
|
EGFR |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56365 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 9528863 |
Betacellulin is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events;ten growth factors and their erbb specificities are depicted: egf, amphiregulin((ar), and tgfalfa bind erbb-1, betacellulin, heparin binding egf-like growth factor, and epiregulin bing both erbb-1 and erbb-4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10209155 |
Betacellulin is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events;ten growth factors and their erbb specificities are depicted: egf, amphiregulin((ar), and tgfalfa bind erbb-1, betacellulin, heparin binding egf-like growth factor, and epiregulin bing both erbb-1 and erbb-4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23382875 |
Betacellulin is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events;ten growth factors and their erbb specificities are depicted: egf, amphiregulin((ar), and tgfalfa bind erbb-1, betacellulin, heparin binding egf-like growth factor, and epiregulin bing both erbb-1 and erbb-4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
Betacellulin is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events;ten growth factors and their erbb specificities are depicted: egf, amphiregulin((ar), and tgfalfa bind erbb-1, betacellulin, heparin binding egf-like growth factor, and epiregulin bing both erbb-1 and erbb-4. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
BTC | up-regulates
binding
|
ERBB4 |
0.723 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22232668 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147823 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16829981 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10209155 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
ADAM10 | up-regulates activity
cleavage
|
BTC |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259839 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26284334 |
Like ADAM17, ADAM10 has also been implicated in the activation of specific EGFR ligands, especially EGF and betacellulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
BTC
- 
- 