| + |
USP6 | up-regulates 
relocalization
|
ARF6 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15509780 |
Here we show that tre17 (also called tre-2 and usp6), a founding member of the tbc family, targets the arf family gtpase arf6, which regulates plasma membrane-endosome trafficking. Surprisingly, tre17 does not function as a gap for arf6 but rather promotes its activation in vivo. Forced expression of tre17 promotes the localization of arf6 to the plasma membrane, leading to arf6 activation, presumably due to facilitated access to membrane-associated guanine nucleotide exchange factors (gefs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP6 | up-regulates quantity by expression 
transcriptional regulation
|
MMP9 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164946 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20418905 |
In this study we show that tre17 is sufficient to induce expression of mmp-9 and mmp-10, in a manner requiring its usp activity, but not its ability to bind arf6. Tre17 induces transcription of mmp-9 through activation of nuclear factor-kappab (nf-kappab), mediated in part by the gtpase rhoa and its effector kinase, rock. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC42 | up-regulates
relocalization
|
USP6 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12612085 |
In quiescent cells, tre17 is localized to intracellular filamentous and punctate structures in the cytoplasm, folded in an inactive conformation. Upon growth factor addition, cdc42 and rac1 become activated and recruit tre17 to the plasma membrane. Stable membrane localization of tre17 also requires polymerized actin. This recruitment process leads to a conformational change in tre17, such that the n-terminal portion of the molecule further stimulates the accumulation of cortical actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAC1 | up-regulates
relocalization
|
USP6 |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98938 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12612085 |
In quiescent cells, tre17 is localized to intracellular filamentous and punctate structures in the cytoplasm, folded in an inactive conformation. Upon growth factor addition, cdc42 and rac1 become activated and recruit tre17 to the plasma membrane. Stable membrane localization of tre17 also requires polymerized actin. This recruitment process leads to a conformational change in tre17, such that the n-terminal portion of the molecule further stimulates the accumulation of cortical actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP6 | up-regulates
|
NfKb-p65/p50 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20418905 |
These data confirm that tre17 activates nfkappab in a usp-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP6 | up-regulates quantity by expression
transcriptional regulation
|
MMP10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164943 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20418905 |
In this study we show that tre17 is sufficient to induce expression of mmp-9 and mmp-10, in a manner requiring its usp activity, but not its ability to bind arf6. Tre17 induces transcription of mmp-9 through activation of nuclear factor-kappab (nf-kappab), mediated in part by the gtpase rhoa and its effector kinase, rock. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
USP6
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- 