3.0
Summary
| Name |  PHBView Modifications |
| Full Name | Prohibitin |
| Synonyms | PHB_HUMAN | |
| Primary ID | P35232 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KIT | up-regulates activity 
phosphorylation
|
PHB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHB | down-regulates quantity by repression 
transcriptional regulation
|
AR | 0.457 |
| Publications: | 1 | |||
| + | TP53 | up-regulates activity
binding
|
PHB | 0.45 |
| Publications: | 1 | |||