Summary

Name PHB
Full Name Prohibitin
Synonyms PHB_HUMAN |
Primary ID P35232
Links - -
Type protein
Relations 2
Function Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding PHB 0.455
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AR 0.462
Publications: 1