Relation Results

Summary

Name MYH10
Full Name Myosin-10
Synonyms Cellular myosin heavy chain, type B, Myosin heavy chain 10, Myosin heavy chain, non-muscle IIb, Non-muscle myosin heavy chain B, NMMHC-B, Non-muscle myosin heavy chain IIb, NMMHC II-b, NMMHC-IIB
Primary ID P35580
Links - -
Type protein
Relations 5
Function Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 i ...
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Type: Score: Layout: SPV 
0.2720.3280.20.3510.322PRKCZMYH10MEF2DPOU2F1MEF2CMEF2A

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCZdown-regulates img/direct_inhibition.png phosphorylation MYH10 0.272
Identifier Residue Sequence Organism Cell Line
SIGNOR-146100 Ser1937 RGGPISFsSSRSGRR Homo sapiens
pmid sentence
After egf stimulation, apkc_ translocates from the nucleus to the cytoplasm (figure 3) and is therefore able to interact with myosin ii-b. apkc_ phosphorylates nmhc ii-b on ser1937, which is located on the nonhelical tailpiece, leading to filament disassembly at certain sites of the cell
Publications: 1 Organism: Homo Sapiens
+ MEF2Dup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH10 0.328
Identifier Residue Sequence Organism Cell Line
SIGNOR-238766 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ POU2F1up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-238772 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
+ MEF2Cup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH10 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-238769 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ MEF2Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH10 0.322
Identifier Residue Sequence Organism Cell Line
SIGNOR-238763 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
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