| + |
PRKDC | down-regulates 
phosphorylation
|
POU2F1 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53258 |
Ser232 |
LTQLPQQsQANLLQS |
Homo sapiens |
|
| pmid |
sentence |
| 9368058 |
Through a similar strategy, t226 and s232 were characterized as the dna-pk phosphorylation sites |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53262 |
Thr226 |
LQAQNLLtQLPQQSQ |
Homo sapiens |
|
| pmid |
sentence |
| 9368058 |
Through a similar strategy, t226 and s232 were characterized as the dna-pk phosphorylation sites |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | down-regulates
phosphorylation
|
POU2F1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53254 |
Ser385 |
RRRKKRTsIETNIRV |
Homo sapiens |
|
| pmid |
sentence |
| 9368058 |
Mitosis-specific phosphorylation site in the homeodomain of oct-1 was phosphorylated in vitro by protein kinase a. Pka-mediated phosphorylation event was identified in the cns-specific pou domain protein brn-2/n-oct-3/pou3f2 (nieto et al. 2007). In this case, the modification, at a position homologous to oct1 s385, was found to alter binding specificity for complex dimeric sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-20971 |
Ser385 |
RRRKKRTsIETNIRV |
Homo sapiens |
|
| pmid |
sentence |
| 1684878 |
Mitosis-specific phosphorylation site in the homeodomain of oct-1 was phosphorylated in vitro by protein kinase a. Pka-mediated phosphorylation event was identified in the cns-specific pou domain protein brn-2/n-oct-3/pou3f2 (nieto et al. 2007). In this case, the modification, at a position homologous to oct1 s385, was found to alter binding specificity for complex dimeric sites. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
POU2F1 | down-regulates quantity by repression 
transcriptional regulation
|
IL4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254505 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 11781715 |
Here we show that NFAT proteins are unable to bind to a combined octamer/NFAT site unless the octamer proteins are competed away |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU2AF1 | up-regulates 
binding
|
POU2F1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100968 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12727885 |
Obf1 enhances transcriptional potential of oct1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGB2 | up-regulates activity
binding
|
POU2F1 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240151 |
|
|
Mus musculus |
S194/5.XXO-1 Cell |
| pmid |
sentence |
| 7720710 |
HMG2 and Oct2 interact via their HMG domains and POU homeodomains, respectively. This interaction is not restricted to Oct2, as other members of the octamer transcription factor family like Oct1 and Oct6 also interact with HMG2. The interaction with HMG2 results in a marked increase in the sequence-specific DNA binding activity of the Oct proteins |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
POU2F1 | up-regulates quantity by expression
transcriptional regulation
|
MYH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238757 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
POU2F1 | up-regulates quantity by expression
transcriptional regulation
|
MYH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238760 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
POU2F1 | up-regulates quantity by expression 
transcriptional regulation
|
SNAI2 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23836662 |
This PER2-OCT1 interaction effectively converted OCT1 sites, which normally activate expression, into repressor sites by recruitment of a polycomb repressor complex including EZH2 and SUZ12, as well as HDAC2. We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU2F1 | up-regulates quantity by expression
transcriptional regulation
|
HOXD10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25301728 |
Knockdown of pou2f1 significantly reduced expression of hoxd10 and d11 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU2F1 | up-regulates quantity by expression
transcriptional regulation
|
MYH10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238772 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
POU2F1 | up-regulates quantity by expression
transcriptional regulation
|
GFI1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254432 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19965638 |
HMGB2 binds to the GFI1B promoter in vivo and up-regulates its trans-activation most likely by enhancing the binding of Oct-1 and, to a lesser extent, of GATA-1 and NF-Y to the GFI1B promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU2F1 | up-regulates quantity by expression
transcriptional regulation
|
TWIST1 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254152 |
|
|
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 23836662 |
This PER2-OCT1 interaction effectively converted OCT1 sites, which normally activate expression, into repressor sites by recruitment of a polycomb repressor complex including EZH2 and SUZ12, as well as HDAC2. We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU2F1 | up-regulates quantity by expression
transcriptional regulation
|
HOXD11 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25301728 |
Knockdown of pou2f1 significantly reduced expression of hoxd10 and d11 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PER2 | down-regulates activity
binding
|
POU2F1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254148 |
|
|
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 23836662 |
This PER2-OCT1 interaction effectively converted OCT1 sites, which normally activate expression, into repressor sites by recruitment of a polycomb repressor complex including EZH2 and SUZ12, as well as HDAC2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
POU2F1
- 
- 