| + |
SRC | down-regulates 
phosphorylation
|
CHRNA7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141307 |
Tyr386 |
ASNGNLLyIGFRGLD |
Homo sapiens |
|
| pmid |
sentence |
| 16251431 |
?7 Neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and src-family kinases |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141311 |
Tyr442 |
KILEEVRyIANRFRC |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16251431 |
Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and src-family kinasesmutant alpha7 nachrs lacking cytoplasmic loop tyrosine residues because of alanine replacement of tyr-386 and tyr-442 were more active than wild-type receptorsexpression of active src reduced _7 nachr activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
acetylcholine | up-regulates activity 
chemical activation
|
CHRNA7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253984 |
|
|
|
|
| pmid |
sentence |
| 27167578 |
Here, we demonstrate a role for α7 nAChR/G protein interaction in the activation of the small (monomeric) RhoA GTPase leading to cytoskeletal changes during neurite growth. Treatment of PC12 cells with the α7 nAChR agonist choline or PNU-282987 was associated with an increase in RhoA activity and an inhibition in neurite growth. |
|
| Publications: |
1 |
| + |
CHRNA7 | form complex 
binding
|
Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2 |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280876 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25460185 |
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The variety of subtypes in the mammalian nervous system, is mainly due to the diversity of the possible combinations of the eleven neuronal subunits (all but α8) expressed in this animal class. nAChR subtypes can be divided into two main classes: 1) αBgtx-sensitive subtypes which can be homomeric or heteromeric, and are made up of the α7, α9 and α10 subunits; and 2) αBtgx-insensitive receptors, which are heteromeric combinations of α2–6 and β2–4 subunits that bind nicotine with high affinity but not αBgtx (Fig. 1B) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHRNA7 | up-regulates activity
binding
|
RHOA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253985 |
|
|
|
|
| pmid |
sentence |
| 27167578 |
Here, we demonstrate a role for α7 nAChR/G protein interaction in the activation of the small (monomeric) RhoA GTPase leading to cytoskeletal changes during neurite growth. Treatment of PC12 cells with the α7 nAChR agonist choline or PNU-282987 was associated with an increase in RhoA activity and an inhibition in neurite growth. |
|
| Publications: |
1 |
4.0
CHRNA7
- 
- 