Relation Results

Summary

Name LONP1
Full Name Lon protease homolog, mitochondrial
Synonyms LONHs, Lon protease-like protein, LONP, Mitochondrial ATP-dependent protease Lon, Serine protease 15 | PRSS15
Primary ID P36776
Links - -
Type protein
Relations 3
Function ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain ...
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Type: Score: Layout: SPV 
0.2550.271AKT1LONP1STAR

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ up-regulates activity img/direct-activation.png phosphorylation LONP1 0.255
Identifier Residue Sequence Organism Cell Line
SIGNOR-265724 Ser173 VFLKRDDsNESDVVE Homo sapiens PC-3 Cell
pmid sentence
In mitochondria, LonP1 is phosphorylated by Akt on Ser173 and Ser181, enhancing its protease activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265725 Ser181 NESDVVEsLDEIYHT Homo sapiens PC-3 Cell
pmid sentence
In mitochondria, LonP1 is phosphorylated by Akt on Ser173 and Ser181, enhancing its protease activity.
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage STAR 0.271
Identifier Residue Sequence Organism Cell Line
SIGNOR-265726 Rattus norvegicus Granulosa Cell
pmid sentence
Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors
Publications: 1 Organism: Rattus Norvegicus
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