| + |
CLOCK/BMAL1 | up-regulates quantity by expression 
transcriptional regulation
|
STAR |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253700 |
|
|
Coturnix japonica |
Ovarian Follicle |
| pmid |
sentence |
| 17431006 |
One such gene was identified, encoding steroidogenic acute regulatory protein (StAR), which showed 24-h changes in expression in the F1 follicle coinciding with those of Per2. Evidence that StAR gene expression is clock driven was obtained by showing that its 5' flanking region contains E-box enhancers that bind to CLOCK/BMAL1 heterodimers to activate gene transcription |
|
| Publications: |
1 |
Organism: |
Coturnix Japonica |
| + |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254043 |
|
|
Homo sapiens |
Endometrial Stromal Cell |
| pmid |
sentence |
| 18583320 |
Electrophoretic mobility shift assay demonstrated that this region of the StAR promoter was bound by C/EBPalpha, C/EBPbeta, and CREB. Forced expression of either C/EBPalpha or C/EBPbeta alone was sufficient to up-regulate StAR promoter activity whereas PGE(2) was needed to induce StAR promoter activity in CREB-overexpressed cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR5A1 | up-regulates quantity by expression 
transcriptional regulation
|
STAR |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254869 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19022561 |
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JUN | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254875 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19022561 |
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254046 |
|
|
Homo sapiens |
Endometrial Stromal Cell |
| pmid |
sentence |
| 18583320 |
Electrophoretic mobility shift assay demonstrated that this region of the StAR promoter was bound by C/EBPalpha, C/EBPbeta, and CREB. Forced expression of either C/EBPalpha or C/EBPbeta alone was sufficient to up-regulate StAR promoter activity whereas PGE(2) was needed to induce StAR promoter activity in CREB-overexpressed cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAR | up-regulates quantity
relocalization
|
cholesterol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265727 |
|
|
|
|
| pmid |
sentence |
| 17579211 |
StAR transfers cholesterol from the outer to the inner mitochondrial membranes, where the enzyme complex of cholesterol side chain cleavage cytochrome P450 (P450scc) converts it to the first steroid, pregnenolone |
|
| Publications: |
1 |
| Pathways: | Sex Hormone Biosynthesis |
| + |
NR5A1 | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271788 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19237537 |
The in vivo existence of an SF-1 corepressor complex consisting of DAX-1, RNF31, and SMRT at the steroidogenic promoters of the human StAR and CYP19 genes. We demonstrate that RNF31 is necessary for the stable association of the DAX-1 corepressor complex with chromatin-bound SF-1, thereby inhibiting the recruitment of coactivators and Pol II and controlling basal transcription levels of SF-1 target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXL2 | down-regulates quantity by repression 
transcriptional regulation
|
STAR |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21862621 |
We previously demonstrated that FOXL2 is a transcriptional repressor of the steroidogenic acute regulatory (StAR), P450SCC (CYP11A), P450aromatase (CYP19), and cyclin D2 (CCND2) genes, markers of ovarian follicle proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LONP1 | down-regulates quantity by destabilization 
cleavage
|
STAR |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265726 |
|
|
Rattus norvegicus |
Granulosa Cell |
| pmid |
sentence |
| 17579211 |
Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
NR5A2 | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254870 |
|
|
Homo sapiens |
Endometrial Cancer Cell Line |
| pmid |
sentence |
| 19022561 |
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOS | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254878 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19022561 |
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
STAR
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