Relation Results

Summary

Name STAR
Full Name Steroidogenic acute regulatory protein, mitochondrial
Synonyms StAR, START domain-containing protein 1, StARD1 | STARD1
Primary ID P49675
Links - -
Type protein
Relations 11
Pathways Sex Hormone Biosynthesis
Function Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from ...
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Type: Score: Layout: SPV 
0.340.4830.2890.2710.3660.3570.80.2620.3720.261CEBPASTARNR5A1CLOCK/BMAL1LONP1FOXL2NR5A2cholesterolJUNCEBPBFOS

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Relations
Regulator
Mechanism
target
score ℹ
+ CEBPAup-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.34
Identifier Residue Sequence Organism Cell Line
SIGNOR-254043 Homo sapiens Endometrial Stromal Cell
pmid sentence
Electrophoretic mobility shift assay demonstrated that this region of the StAR promoter was bound by C/EBPalpha, C/EBPbeta, and CREB. Forced expression of either C/EBPalpha or C/EBPbeta alone was sufficient to up-regulate StAR promoter activity whereas PGE(2) was needed to induce StAR promoter activity in CREB-overexpressed cells.
Publications: 1 Organism: Homo Sapiens
+ NR5A1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation STAR 0.483
Identifier Residue Sequence Organism Cell Line
SIGNOR-254869 Homo sapiens
pmid sentence
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters.
Publications: 1 Organism: Homo Sapiens
+ CLOCK/BMAL1up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.289
Identifier Residue Sequence Organism Cell Line
SIGNOR-253700 Coturnix japonica Ovarian Follicle
pmid sentence
One such gene was identified, encoding steroidogenic acute regulatory protein (StAR), which showed 24-h changes in expression in the F1 follicle coinciding with those of Per2. Evidence that StAR gene expression is clock driven was obtained by showing that its 5' flanking region contains E-box enhancers that bind to CLOCK/BMAL1 heterodimers to activate gene transcription
Publications: 1 Organism: Coturnix Japonica
+ LONP1down-regulates quantity by destabilization img/direct_inhibition.png cleavage STAR 0.271
Identifier Residue Sequence Organism Cell Line
SIGNOR-265726 Rattus norvegicus Granulosa Cell
pmid sentence
Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors
Publications: 1 Organism: Rattus Norvegicus
+ FOXL2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation STAR 0.366
Identifier Residue Sequence Organism Cell Line
SIGNOR-254180 Homo sapiens
pmid sentence
We previously demonstrated that FOXL2 is a transcriptional repressor of the steroidogenic acute regulatory (StAR), P450SCC (CYP11A), P450aromatase (CYP19), and cyclin D2 (CCND2) genes, markers of ovarian follicle proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
+ NR5A2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation STAR 0.357
Identifier Residue Sequence Organism Cell Line
SIGNOR-254870 Homo sapiens Endometrial Cancer Cell Line
pmid sentence
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters.
Publications: 1 Organism: Homo Sapiens
+ STARup-regulates quantity img/direct-activation.png relocalization cholesterol 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-265727
pmid sentence
StAR transfers cholesterol from the outer to the inner mitochondrial membranes, where the enzyme complex of cholesterol side chain cleavage cytochrome P450 (P450scc) converts it to the first steroid, pregnenolone
Publications: 1
Pathways:Sex Hormone Biosynthesis
+ JUNup-regulates quantity by expression img/indirect-activation.png transcriptional regulation STAR 0.262
Identifier Residue Sequence Organism Cell Line
SIGNOR-254875 Homo sapiens
pmid sentence
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters.
Publications: 1 Organism: Homo Sapiens
+ CEBPBup-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-254046 Homo sapiens Endometrial Stromal Cell
pmid sentence
Electrophoretic mobility shift assay demonstrated that this region of the StAR promoter was bound by C/EBPalpha, C/EBPbeta, and CREB. Forced expression of either C/EBPalpha or C/EBPbeta alone was sufficient to up-regulate StAR promoter activity whereas PGE(2) was needed to induce StAR promoter activity in CREB-overexpressed cells.
Publications: 1 Organism: Homo Sapiens
+ FOSup-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-254878 Homo sapiens
pmid sentence
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters.
Publications: 1 Organism: Homo Sapiens
+ NR5A1up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.483
Identifier Residue Sequence Organism Cell Line
SIGNOR-271788 Homo sapiens
pmid sentence
The in vivo existence of an SF-1 corepressor complex consisting of DAX-1, RNF31, and SMRT at the steroidogenic promoters of the human StAR and CYP19 genes. We demonstrate that RNF31 is necessary for the stable association of the DAX-1 corepressor complex with chromatin-bound SF-1, thereby inhibiting the recruitment of coactivators and Pol II and controlling basal transcription levels of SF-1 target genes.
Publications: 1 Organism: Homo Sapiens
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