| + |
E2F1 | up-regulates quantity by expression 
transcriptional regulation
|
SERPINB5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254135 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 20197383 |
Importantly, we show that E2F1-mediated upregulation of maspin is enhanced by chemotherapeutic drugs, and inhibition of maspin expression significantly impairs the ability of E2F1 to promote chemotherapy-induced apoptosis. Summarily, our data indicate that maspin is an important effector of E2F1-induced chemosensitization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | down-regulates quantity by repression 
transcriptional regulation
|
SERPINB5 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268494 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 18247378 |
We found that maspin is selectively upregulated in IFIXα-expressing cells and involved in anti-invasive activity of IFIXα. We also present evidence indicating that IFIXα downregulates histone deacetylase 1 (HDAC1), which is possibly involved in the silencing of the maspin gene in human breast cancer cells. To confirm these results, we performed a luciferase assay using a maspin-promoter-luciferase plasmid. The results showed that HDAC1 overexpression suppressed the activity of the maspin promoter (Figure 3C). Therefore, our results suggest that IFIXα enhances maspin expression through the downregulation of HDAC1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AR | down-regulates quantity by repression
transcriptional regulation
|
SERPINB5 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253685 |
|
|
|
|
| pmid |
sentence |
| 16304843 |
In addition, androgen receptor (AR) can recognize and bind to the ARE element, and then inhibit the activity of maspin promoter |
|
| Publications: |
1 |
3.0
SERPINB5
- 
- 