Summary

Name HDAC1
Full Name Histone deacetylase 1
Synonyms HD1 | RPD3L1
Primary ID Q13547
Links - -
Type protein
Relations 79
Pathways FAP: In vitro induction of adipogenesis, FAP: Glucocorticoids, Myofiber: BMP, Prostate Cancer, Pericyte: In vitro induction of adipogenesis
Inhibitors panobinostat; trichostatin A; tacedinaline; N-[4-[(hydroxyamino)-oxomethyl]phenyl]carbamic acid [6-(diethylaminomethyl)-2-naphthalenyl]methyl ester; N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide; entinostat; Dacinostat; vorinostat; CUDC-907; JWOGUUIOCYMBPV-GMFLJSBRSA-N; N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide; belinostat; 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide; romidepsin; 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide; (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide; CUDC-101; N-hydroxy-2-[4-[[(1-methyl-3-indolyl)methylamino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png deacetylation FLI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HDAC1 0.617
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HDAC1 0.411
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HDAC1 0.292
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HDAC1 0.405
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC1 0.457
Publications: 1 Organism: Rattus Norvegicus
+ form complex img/form-complex.png binding SMAD7/HDAC1/E2F-1 0.639
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png transcriptional regulation CEBPA 0.449
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding HDAC1 0.323
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ABCB1 0.289
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation HES1 0.381
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png deacetylation YY1 0.789
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SNAI2 0.593
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HDAC1 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GAD1 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation VDR 0.395
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DNMT1 0.775
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KLK3 0.301
Publications: 1
+ up-regulates img/direct-activation.png binding HDAC1 0.441
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding MBD2/NuRD complex 0.819
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MYOD1 0.561
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPA 0.449
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FSHR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ESR1 0.64
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RELA 0.592
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EGR1 0.551
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation UBE2D3 0.266
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding HDAC1 0.286
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RELN 0.279
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CCND1 0.682
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding MBD3/NuRD complex 0.821
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NfKb-p65/p50 0.562
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation GLI1 0.577
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding HDAC1 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding Sin3B_complex 0.789
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC1 0.404
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SERPINB5 0.424
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC1 0.637
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation FOXO3 0.372
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding HDAC1 0.516
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HDAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation FOXO 0.372
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
+ up-regulates activity img/direct-activation.png relocalization HDAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png relocalization HDAC1 0.6
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates img/direct_inhibition.png chemical inhibition HDAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MECP2/SIN3A/HDAC complex 0.745
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HSPA5 0.262
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding BHC complex 0.717
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CLDN7 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CoREST-HDAC complex 0.698
Publications: 1 Organism: Homo Sapiens