Summary

Name GRIK1
Full Name Glutamate receptor ionotropic, kainate 1
Synonyms GluK1, Excitatory amino acid receptor 3, EAA3, Glutamate receptor 5, GluR-5, GluR5 | GLUR5
Primary ID P39086
Links - -
Type protein
Relations 4
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

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Relations

Regulator Mechanism target score ℹ
+ GRIK1up-regulates quantity img/direct-activation.png relocalization D-serine 0.8
Publications: 1 Organism: Homo Sapiens
+ GRIK1up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation GRIK1 0.8
Publications: 1 Organism: Homo Sapiens
+ GRIK1up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Publications: 1 Organism: Homo Sapiens