Relation Results

Summary

Name GRIK1
Full Name Glutamate receptor ionotropic, kainate 1
Synonyms GluK1, Excitatory amino acid receptor 3, EAA3, Glutamate receptor 5, GluR-5, GluR5 | GLUR5
Primary ID P39086
Links - -
Type protein
Relations 4
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excit ...
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Type: Score: Layout: SPV 
0.80.80.70.8GRIK1calcium(2+)glutamic acidExcitatory_synaptic_transmissionD-serine

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Relations
Regulator
Mechanism
target
score ℹ
+ GRIK1up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264942 Homo sapiens
pmid sentence
Ca2+ is arguably the most important second messenger in the brain because of its pivotal roles in presynaptic neurotransmitter release, postsynaptic responses, and plasticity induction. iGluRs and mGluRs can generate intracellular Ca2+ signals, albeit by different mechanisms, whose crosstalk has not been thoroughly explored (Figure 2C). iGluRs allow the influx of extracellular Ca2+ upon pore opening. This is widely acknowledged for NMDARs, which have a high Ca2+ conductance, but Ca2+ flux through AMPARs and KARs can still be substantial.
Publications: 1 Organism: Homo Sapiens
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation GRIK1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264470 Homo sapiens
pmid sentence
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its biological activity through a variety of receptors. Glutamate receptors (GluRs) are divided into two major classes on the basis of the mechanism by which they relay their signal: the ionotropic glutamate receptors (iGluRs), which are ligand-gated cation channels, and the metabotropic glutamate receptors (mGluRs) that are G protein-coupled receptors
Publications: 1 Organism: Homo Sapiens
+ GRIK1up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264342 Homo sapiens Neuron
pmid sentence
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic.
Publications: 1 Organism: Homo Sapiens
+ GRIK1up-regulates quantity img/direct-activation.png relocalization D-serine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268272 Homo sapiens Astroglial Cell
pmid sentence
Glutamate (L-Glu) released from neurons interacts with kainate-type of glutamate receptors (Kain-R) in astrocytes to stimulate release of D-serine
Publications: 1 Organism: Homo Sapiens
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