| + |
D-serine | up-regulates activity 
chemical activation
|
NMDA receptor_2D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268280 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
D-serine acts in concert with L-glutamate (triangles) to activate NMDA receptors|D-serine released from astrocytes seems to be an endogenous ligand of the N-methyl-D-aspartate (NMDA) receptor (3, 8). Depletion of endogenous D-serine in slices and cultured cells strongly diminishes NMDA receptor responses measured biochemically and electrophysiologically |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
L-serine | up-regulates quantity
precursor of
|
D-serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268271 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12393813 |
High levels of d-serine occur in the brain, challenging the notion that d-amino acids would not be present or play a role in mammals. d-serine levels in the brain are even higher than many l-amino acids, such as asparagine, valine, isoleucine, and tryptophan, among others. d-serine is synthesized by a serine racemase (SR) enzyme, which directly converts l- to d-serine. We now report that SR is a bifunctional enzyme, producing both d-serine and pyruvate in cultured cells and in vitro. Transfection of SR into HEK 293 cells elicits synthesis of d-serine and augmented release of pyruvate to culture media. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
GRIK5 | up-regulates quantity
relocalization
|
D-serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268276 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
Glutamate (L-Glu) released from neurons interacts with kainate-type of glutamate receptors (Kain-R) in astrocytes to stimulate release of D-serine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRR | up-regulates quantity
chemical modification
|
D-serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268270 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12393813 |
High levels of d-serine occur in the brain, challenging the notion that d-amino acids would not be present or play a role in mammals. d-serine levels in the brain are even higher than many l-amino acids, such as asparagine, valine, isoleucine, and tryptophan, among others. d-serine is synthesized by a serine racemase (SR) enzyme, which directly converts l- to d-serine. We now report that SR is a bifunctional enzyme, producing both d-serine and pyruvate in cultured cells and in vitro. Transfection of SR into HEK 293 cells elicits synthesis of d-serine and augmented release of pyruvate to culture media. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
D-serine | up-regulates activity
chemical activation
|
NMDA receptor_2C |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268279 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
D-serine acts in concert with L-glutamate (triangles) to activate NMDA receptors|D-serine released from astrocytes seems to be an endogenous ligand of the N-methyl-D-aspartate (NMDA) receptor (3, 8). Depletion of endogenous D-serine in slices and cultured cells strongly diminishes NMDA receptor responses measured biochemically and electrophysiologically |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
D-serine | up-regulates activity
chemical activation
|
NMDA receptor_2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268278 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
D-serine acts in concert with L-glutamate (triangles) to activate NMDA receptors|D-serine released from astrocytes seems to be an endogenous ligand of the N-methyl-D-aspartate (NMDA) receptor (3, 8). Depletion of endogenous D-serine in slices and cultured cells strongly diminishes NMDA receptor responses measured biochemically and electrophysiologically |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIK3 | up-regulates quantity
relocalization
|
D-serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268274 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
Glutamate (L-Glu) released from neurons interacts with kainate-type of glutamate receptors (Kain-R) in astrocytes to stimulate release of D-serine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIK2 | up-regulates quantity
relocalization
|
D-serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268273 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
Glutamate (L-Glu) released from neurons interacts with kainate-type of glutamate receptors (Kain-R) in astrocytes to stimulate release of D-serine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
D-serine | up-regulates activity
chemical activation
|
NMDA receptor_2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268277 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
D-serine acts in concert with L-glutamate (triangles) to activate NMDA receptors|D-serine released from astrocytes seems to be an endogenous ligand of the N-methyl-D-aspartate (NMDA) receptor (3, 8). Depletion of endogenous D-serine in slices and cultured cells strongly diminishes NMDA receptor responses measured biochemically and electrophysiologically |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIK1 | up-regulates quantity
relocalization
|
D-serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268272 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
Glutamate (L-Glu) released from neurons interacts with kainate-type of glutamate receptors (Kain-R) in astrocytes to stimulate release of D-serine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIK4 | up-regulates quantity
relocalization
|
D-serine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268275 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
Glutamate (L-Glu) released from neurons interacts with kainate-type of glutamate receptors (Kain-R) in astrocytes to stimulate release of D-serine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
D-serine