Relation Results

Name	CUX1 View Modifications
Full Name	Homeobox protein cut-like 1
Synonyms	CCAAT displacement protein, CDP, Homeobox protein cux-1 \| CUTL1
Primary ID	P39880
Links	- -
Type	protein
Relations	3
Pathways	Acute Myeloid Leukemia, KIT in AML
Function	Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.