Summary

Name OPRK1
Full Name Kappa-type opioid receptor
Synonyms K-OR-1, KOR-1 | OPRK
Primary ID P41145
Links - -
Type protein
Relations 49
Inhibitors alvimopan; methylnaltrexone; Quadazocine; Naltriben; buprenorphine; naloxone; Diprenorphine; Norbinaltorphimine; naltrexone; beta-Funaltrexamine; (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-6-(phenylmethylene)-1,2,4,5,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one; Nalmefene; Naltrindole
Function G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAO1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI3 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Longicaudatus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.14
Publications: 2 Organism: Homo Sapiens, Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding, chemical activation OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation OPRK1 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAZ 0.08
Publications: 1 Organism: Homo Sapiens