| + |
CHUK | up-regulates activity 
phosphorylation
|
MECP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279459 |
Ser423 |
EKMPRGGsLESDGCP |
Homo sapiens |
|
| pmid |
sentence |
| 22848609 |
Representative confocal micrographs of 4th day differentiating cultures are shown. (C) IKK\u03b1 promotes MeCP2-dependent BDNF expression.|The characterization of IKK\u03b1-mediated phosphorylation of MeCP2 at Ser421 and other residues and their effects on the activity of MeCP2 is a topic of current work in our laboratory. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIPK2 | up-regulates activity
phosphorylation
|
MECP2 |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264549 |
Ser80 |
AVPEASAsPKQRRSI |
Homo sapiens |
|
| pmid |
sentence |
| 19820693 |
Here, we identify the homeodomain-interacting protein kinase 2 (HIPK2) as a kinase that binds MeCP2 and phosphorylates it at Ser 80 in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression 
transcriptional regulation
|
BDNF |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254023 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18599437 |
MeCP2 is involved in gene silencing and known to affect the activity of brain-derived neurotrophic factor (BDNF) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression 
transcriptional regulation
|
CRH |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264548 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 17108082 |
Collectively, these results point to a specific association between WT MeCP2 and the methylated promoter region of Crh in vivo. In contrast, the MeCP2308 protein was not detected at the Crh promoter. | Thus, the results of seqChIP indicate that MeCP2 preferentially associates with a transcriptionally inactive, dimethyl-histone H3 Lys-9-rich form of the Crh promoter in mice. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MECP2 | down-regulates quantity by repression
post transcriptional regulation
|
MET |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264683 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24150225 |
MeCP2 binding enhances MET expression in the presence of the rs1858830 C allele, but MET transcription is attenuated by RTT-specific mutations in MeCP2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
AMPA |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270237 |
|
|
Rattus norvegicus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 22262897 |
Bicuculline treatment also leads to an increase in the levels of the transcriptional repressor MeCP2, which binds to the GluR2 promoter along with the corepressors HDAC1 and mSin3A. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
ALOX5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254062 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 19781662 |
Human 5-lipoxygenase (5-LO) is the key enzyme in the formation of inflammatory leukotrienes. 5-LO gene expression is mainly restricted to B cells and cells of myeloid origin. It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation.|Using ChIP assays, we found that the methyl-DNA binding proteins MBD1, MBD2 and MeCP2 bind to the methylated 5-LO core promoter in U937 cells. Knock down of each of the MBDs upregulates 5-LO mRNA expression in U937 cells indicating that these proteins are involved in silencing of the 5-LO gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | up-regulates activity
binding
|
PRPF3 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277691 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21070191 |
MeCP2 interacts directly with Prpf3 and Sdccag1|Notably, Mecp2308/Y mice, which produce a truncated form of MeCP2 and reproduce many of the classical features of RTT [43], have been shown to have multiple genes that are abnormally spliced in the brain [23]. This suggests the C-terminal portion of MeCP2, which we have identified as the putative Sdccag1 interaction domain, plays a critical role in regulating alternative splicing. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
MECP2 | up-regulates quantity by expression
post transcriptional regulation
|
SST |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264676 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18511691 |
MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
BDNF |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264540 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 14593183 |
We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
ESR1 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254024 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 23242655 |
Our previous studies demonstrated that mutant p53 along with repression complex proteins including DNMT1, HDAC1 and MeCP2 is associated with ER-negative promoter in MDA-MB-468 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254573 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15870696 |
Valproate (VPA) induces silencing of the ERalpha, cyclin D1 and pS2 promoters. Chromatin immunoprecipitation (ChIP) analysis demonstrates that VPA induces recruitment of the 5-MeCpG binding protein MeCP2 to the ERalpha A promoter and also to the pS2 and cyclin D1 promoters |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264680 |
|
|
Mus musculus |
Hypothalamus |
| pmid |
sentence |
| 18511691 |
MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | up-regulates quantity by expression
post transcriptional regulation
|
OPRK1 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264677 |
|
|
Mus musculus |
Hypothalamus |
| pmid |
sentence |
| 18511691 |
MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
IGFBP3 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17278996 |
We found that MeCP2 directly regulates expression of insulin-like growth factor binding protein 3 (IGFBP3) gene in human and mouse brains. IGFBP3 overexpression was observed in the brains of mecp2-null mice and human RTT patients using real-time quantitative polymerase chain reaction and Western blot analyses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| Pathways: | Rett syndrome |
| + |
CDKL5 |
phosphorylation
|
MECP2 |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264702 |
|
|
in vitro |
|
| pmid |
sentence |
| 16935860 |
Phosphorylation assays performed with the wild-type protein confirm its capability to mediate the modification of MeCP2 in vitro, whereas Rett missense mutations within the conserved catalytic domain abrogate or significantly impair the enzymatic activity |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
PTPN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264546 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 26214522 |
In this study, we have demonstrated that the PTPN1 gene, which encodes PTP1B, was a direct target of MECP2 and that PTP1B protein levels were dramatically increased in Mecp2-mutant mice and in fibroblasts derived from patients with RTT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
ABCB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254033 |
|
|
|
|
| pmid |
sentence |
| 11865062 |
We have established that methyl-CpG binding protein 2 (MeCP2) is involved in methylation-dependent silencing of human MDR1 in cells that lack the known transcriptional repressors MBD2 and MBD3. In the repressed state the MDR1 promoter is methylated and assembled into chromatin enriched with MeCP2 and deacetylated histone. TSA induced significant acetylation of histones H3 and H4 but did not activate transcription. 5aC induced DNA demethylation, leading to the release of MeCP2, promoter acetylation, and partial relief of repression |
|
| Publications: |
1 |
| + |
MECP2 | up-regulates 
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264967 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25420914 |
Our current study highlights the phosphorylation, but not the overall expression level, of MeCP2 as a significant regulatory mechanism in regulating adult neurogenesis in the hippocampus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264966 |
|
|
Mus musculus |
Neural Stem Cell |
| pmid |
sentence |
| 19427855 |
Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2 |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Hippocampus |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
RBFOX1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264681 |
|
|
Mus musculus |
Hypothalamus |
| pmid |
sentence |
| 18511691 |
MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MECP2 | up-regulates activity
binding
|
YBX1 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277700 |
|
|
|
|
| pmid |
sentence |
| 16251272 |
In this study, we show that MeCP2 interacts with the RNA-binding protein Y box-binding protein 1 and regulates splicing of reporter minigenes. Importantly, we found aberrant alternative splicing patterns in a mouse model of RTT. Thus, we uncovered a previously uncharacterized function of MeCP2 that involves regulation of splicing, in addition to its role as a transcriptional repressor. |
|
| Publications: |
1 |
| + |
MECP2 | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264550 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 19820693 |
We show that MeCP2 cooperates with HIPK2 in induction of apoptosis and that Ser 80 phosphorylation is required together with the DNA binding of MeCP2. | We found increased cell death in each of the tested cell lines not only, as expected, when HIPK2 was overexpressed but also with MeCP2 alone. When both proteins were expressed together, the number of dead cells increased in an additive manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML, Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
MGMT |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254035 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15657354 |
Chromatin immunoprecipitation analysis of methyl-CpG binding domain containing proteins detected a greater amount of MeCP2, MBD1, and CAF-1 bound to the MGMT promoter in MGMT-silenced cells. Our findings implicate specific MBD proteins in methylation-mediated transcriptional silencing of MGMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | up-regulates quantity by expression
post transcriptional regulation
|
CREB1 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264682 |
|
|
Mus musculus |
Hypothalamus |
| pmid |
sentence |
| 18511691 |
Interestingly, Creb1 was one of the activated MeCP2 targets that we validated by quantitative real-time RT-PCR (Fig. 1C), and using ChIP analysis we found that in vivo MeCP2 binds to the promoter region of Creb1, with significantly enhanced binding in MECP2-Tg samples compared to WT (p < 0.05) | In addition, Sst and CREB1 protein levels were increased in MECP2-Tg hypothalami compared to WT, indicating that MeCP2 indeed enhances expression of Sst and Creb1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | up-regulates activity
binding
|
DEAF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269063 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 29636529 |
We show that MeCP2 enhances Deaf1 binding to its HTR1A site and co-immunoprecipitates with Deaf1 in cells and brain tissue.To address the role of MeCP2 in HTR1A regulation in vivo, mice with conditional knockout of MeCP2 in adult 5-HT neurons (MeCP2 cKO) were generated. These mice exhibited increased 5-HT1A autoreceptor levels and function, consistent with MeCP2 enhancement of Deaf1 repression in 5-HT neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
FKBP5 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264542 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16002417 |
These results are compatible with the hypothesis that MeCP2 associates with the Sgk and Fkbp5 promoters and has a repressive effect that is over-ridden by elevated glucocorticoids in response to stress. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | up-regulates activity
binding
|
DNMT1 |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264541 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12473678 |
Thus, these results indicate that MeCP2-interacting Dnmt1 has significant maintenance DNA methyltransferase activity and that MeCP2 does not vanish Dnmt1 enzymatic activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
RELN |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254578 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
MECP2 | up-regulates quantity by expression
post transcriptional regulation
|
GAMT |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264678 |
|
|
Mus musculus |
Hypothalamus |
| pmid |
sentence |
| 18511691 |
MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
GAD1 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254579 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
SGK1 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264543 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16002417 |
These results are compatible with the hypothesis that MeCP2 associates with the Sgk and Fkbp5 promoters and has a repressive effect that is over-ridden by elevated glucocorticoids in response to stress. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
MECP2 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254025 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20513142 |
Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression|In these patients we found diminished MECP2 and CDKL5 expression in vivo, and transcriptional reporter assays indicated that MEF2C mutations diminish synergistic transactivation of E-box promoters including that of MECP2 and CDKL5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
GRIA2 |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264684 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 22262897 |
Bicuculline treatment also leads to an increase in the levels of the transcriptional repressor MeCP2, which binds to the GluR2 promoter along with the corepressors HDAC1 and mSin3A. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
DLL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264674 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25420914 |
As the first step to reveal how MeCP2 phosphorylation may regulate Notch signaling, we conducted chromatin immunoprecipitation (ChIP) experiment to determine whether the phosphor-mutant MeCP2 protein has altered promoter occupancy at the promoters of Dll1 and Notch1. We found increased binding of the phosphor-mutant protein at the promoters of both Dll1 and Notch1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | up-regulates quantity by expression
post transcriptional regulation
|
miR-199a |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255765 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24708856 |
We found overexpression of miR-155 led to increase in cJUN, FOS and TRIB2, and decrease in MEIS1, GFI1, cMYC and JARID2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
MECP2 | up-regulates activity
binding
|
NEMF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277692 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21070191 |
MeCP2 interacts directly with Prpf3 and Sdccag1|MeCP2’s association with Prpf3, a major component of the spliceosome, supports MeCP2 as having a role in modulating mRNA splicing|Notably, Mecp2308/Y mice, which produce a truncated form of MeCP2 and reproduce many of the classical features of RTT [43], have been shown to have multiple genes that are abnormally spliced in the brain [23]. This suggests the C-terminal portion of MeCP2, which we have identified as the putative Sdccag1 interaction domain, plays a critical role in regulating alternative splicing. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
CCND1 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254571 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15870696 |
Valproate (VPA) induces silencing of the ERalpha, cyclin D1 and pS2 promoters. Chromatin immunoprecipitation (ChIP) analysis demonstrates that VPA induces recruitment of the 5-MeCpG binding protein MeCP2 to the ERalpha A promoter and also to the pS2 and cyclin D1 promoters |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
DLX5 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254034 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19195802 |
Expression of DLX5 is controlled by MECP2, and defect in MECP2 induced an over-expression of DLX5 in lymphocytes as well as in the brain |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | form complex 
binding
|
MECP2/SIN3A/HDAC complex |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265070 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9620804 |
We show that a region of MeCP2 that localizes with the TRD associates with a corepressor complex containing the transcriptional repressor mSin3A and histone deacetylases. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
GRIN2B |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264685 |
|
|
Rattus norvegicus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 18952054 |
The interaction of MeCP2 with the 2BI3 and 2BI5 sites was strikingly reduced in neurons maintained in the presence of TTX (Fig. 2C). This result is consistent with the classical view of MeCP2 as a general transcriptional repressor, in that the reduced association leads to increased expression of NR2B. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MECP2 | up-regulates
|
Neuron_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264968 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17532643 |
Our studies suggest that MeCP2 plays a central role in neuronal maturation, which might be mediated through epigenetic control of expression pathways that are instrumental in both dendritic development and synaptogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Hippocampus |
| Pathways: | Rett syndrome |
| + |
miR-132 | down-regulates quantity by repression
post transcriptional regulation
|
MECP2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255884 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23132946 |
In human leukemic cells with MLL rearrangements (e.g., MONOMAC-6 and THP-1 cells), we found that ectopic expression of miR-495 could significantly inhibit cell growth/proliferation and increase apoptosis while decreasing cell viability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256649 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23132946 |
In human leukemic cells with MLL rearrangements (e.g., MONOMAC-6 and THP-1 cells), we found that ectopic expression of miR-495 could significantly inhibit cell growth/proliferation and increase apoptosis while decreasing cell viability. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
NOTCH1 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264675 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25420914 |
As the first step to reveal how MeCP2 phosphorylation may regulate Notch signaling, we conducted chromatin immunoprecipitation (ChIP) experiment to determine whether the phosphor-mutant MeCP2 protein has altered promoter occupancy at the promoters of Dll1 and Notch1. We found increased binding of the phosphor-mutant protein at the promoters of both Dll1 and Notch1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, Rett syndrome |
| + |
MECP2 | up-regulates quantity by expression
post transcriptional regulation
|
GPRIN1 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264679 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18511691 |
MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
TFF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254572 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15870696 |
Valproate (VPA) induces silencing of the ERalpha, cyclin D1 and pS2 promoters. Chromatin immunoprecipitation (ChIP) analysis demonstrates that VPA induces recruitment of the 5-MeCpG binding protein MeCP2 to the ERalpha A promoter and also to the pS2 and cyclin D1 promoters |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
PTPN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264552 |
|
|
Mus musculus |
Forebrain |
| pmid |
sentence |
| 26214522 |
We demonstrated that the PTPN1 gene, which encodes PTP1B, was a target of MECP2 and that disruption of MECP2 function was associated with increased levels of PTP1B in RTT models. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MECP2 | up-regulates activity
binding
|
TET1 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277701 |
|
|
|
|
| pmid |
sentence |
| 28594324 |
MeCP2 and its partners, splicing factor Y-box binding protein 1 (YB-1) and methylcytosine dioxygenase 1 (Tet1), bind to BDNF chromatin in naı ̈ve but dissociate during conditioning|Knockdown of MeCP2 shows it is instrumental for splicing and inhibits Tet1 and CTCF binding thereby negatively impacting DNA methylation and conditioning-dependent splicing regulation. Thus, mutations in MECP2 can have secondary effects on DNA methylation and alternative splicing. |
|
| Publications: |
1 |
3.0
MECP2
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