3.0
Summary
| Name |  AQP2View Modifications |
| Full Name | Aquaporin-2 |
| Synonyms | AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct | |
| Primary ID | P41181 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:8140421, PubMed:7524315, PubMed:7510718, PubMed:15509592). Plays an essential role in renal water homeostasis (PubMed:8140421, PubMed:7524315, PubMed:15509592). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PKA | up-regulates activity 
phosphorylation
|
AQP2 | 0.2 |
| Publications: | 1 | Organism: | Canis Lupus Familiaris | |
| + | CyclinA2/CDK18 | down-regulates quantity by destabilization 
phosphorylation
|
AQP2 | 0.263 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK18 | down-regulates quantity by destabilization
phosphorylation
|
AQP2 | 0.263 |
| Publications: | 1 | Organism: | Homo Sapiens | |